Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares

We have previously demonstrated that intranasal administration of ambient ultrafine particles (UFP) acts as an adjuvant for primary allergic sensitization to ovalbumin (OVA) in Balb/c mice. It is important to find out whether inhaled UFP exert the same effect on the secondary immune response as a wa...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2010-09, Vol.299 (3), p.L374-L383
Hauptverfasser:	Li, Ning, Harkema, Jack R, Lewandowski, Ryan P, Wang, Meiying, Bramble, Lori A, Gookin, Glenn R, Ning, Zhi, Kleinman, Michael T, Sioutas, Constantinos, Nel, Andre E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Administration, Inhalation Allergies Animals Antibody Formation - drug effects Asthma Asthma - physiopathology Cytokines Cytokines - metabolism Female Gene Expression Hypersensitivity - complications Immune system Inflammation - etiology Inflammation - pathology Inflammation - physiopathology Lung - drug effects Lung - pathology Mice Mice, Inbred BALB C Ovalbumin - immunology Oxidation Particulate Matter - administration & dosage Respiratory System - immunology Respiratory Tract Diseases - etiology Respiratory Tract Diseases - pathology Respiratory Tract Diseases - physiopathology Rodents Severity of Illness Index Vehicle Emissions
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