Acute and Chronic Alcohol Exposure Impair the Phagocytosis of Apoptotic Cells and Enhance the Pulmonary Inflammatory Response

Background: Alcohol abuse increases the risk for acute respiratory distress syndrome (ARDS). Efferocytosis, the clearance of apoptotic cells, is important in the resolution of inflammation and is regulated by RhoA and rho kinase (ROCK) activation. The effects of alcohol on pulmonary Rho pathway act...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2010-10, Vol.34 (10), p.1723-1732
Hauptverfasser:	Boé, Darren M., Richens, Tiffany R., Horstmann, Sarah A., Burnham, Ellen L., Janssen, William J., Henson, Peter M., Moss, Marc, William Vandivier, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute effects Acute Respiratory Distress Syndrome Alcohol Alcoholism and acute alcohol poisoning Amides - pharmacology Animals Apoptosis - physiology Biological and medical sciences Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule Efferocytosis Ethanol - administration & dosage Ethanol - adverse effects Female Lipopolysaccharides Macrophages, Alveolar - metabolism Medical sciences Mice Mice, Inbred C57BL Phagocytosis - drug effects Phagocytosis - physiology Pneumonia - chemically induced Pneumonia - physiopathology Pyridines - pharmacology Respiratory Distress Syndrome, Adult - chemically induced Respiratory Distress Syndrome, Adult - metabolism Respiratory Distress Syndrome, Adult - physiopathology rho GTP-Binding Proteins - analysis Rho Kinase rho-Associated Kinases - antagonists & inhibitors RhoA Toxicology
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