Gene Expression Levels as Predictive Markers of Outcome in Pancreatic Cancer after Gemcitabine-Based Adjuvant Chemotherapy

BACKGROUND AND AIMS: The standard palliative chemotherapy for pancreatic ductal adenocarcinoma (PDAC) is gemcitabine-based chemotherapy; however, PDAC still presents a major therapeutic challenge. The aims of this study were to investigate the expression pattern of genes involved in gemcitabine sens...

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Veröffentlicht in:	Neoplasia (New York, N.Y.) N.Y.), 2010-10, Vol.12 (10), p.807,IN7-817,IN8
Hauptverfasser:	Fujita, Hayato, Ohuchida, Kenoki, Mizumoto, Kazuhiro, Itaba, Soichi, Ito, Tetsuhide, Nakata, Kohei, Yu, Jun, Kayashima, Tadashi, Souzaki, Ryota, Tajiri, Tatsuro, Manabe, Tatsuya, Ohtsuka, Takao, Tanaka, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - therapeutic use Biomarkers, Tumor - genetics Biopsy, Fine-Needle Carcinoma, Adenosquamous - drug therapy Carcinoma, Adenosquamous - genetics Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Deoxycytidine Kinase - genetics Deoxycytidine Kinase - metabolism Equilibrative Nucleoside Transporter 1 - genetics Equilibrative Nucleoside Transporter 1 - metabolism Feasibility Studies Female Gene Expression Profiling Gene Expression Regulation, Neoplastic - physiology Humans Immunoenzyme Techniques Male Middle Aged Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Reverse Transcriptase Polymerase Chain Reaction Ribonucleoside Diphosphate Reductase - genetics Ribonucleoside Diphosphate Reductase - metabolism RNA, Messenger - genetics Survival Rate Treatment Outcome Tumor Cells, Cultured Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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