Executive Function, Memory, and Gait Speed Decline in Well-Functioning Older Adults
Background. In community-dwelling older adults, global cognitive function predicts longitudinal gait speed decline. Few prospective studies have evaluated whether specific executive cognitive deficits in aging may account for gait slowing over time. Methods. Multiple cognitive tasks were administere...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2010-10, Vol.65A (10), p.1093-1100 |
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| creator | Watson, N. L. Rosano, C. Boudreau, R. M. Simonsick, E. M. Ferrucci, L. Sutton-Tyrrell, K. Hardy, S. E. Atkinson, H. H. Yaffe, K. Satterfield, S. Harris, T. B. Newman, A. B. |
| description | Background. In community-dwelling older adults, global cognitive function predicts longitudinal gait speed decline. Few prospective studies have evaluated whether specific executive cognitive deficits in aging may account for gait slowing over time. Methods. Multiple cognitive tasks were administered at baseline in 909 participants in the Health, Aging, and Body Composition Study Cognitive Vitality Substudy (mean age 75.2 ± 2.8 years, 50.6% women, 48.4% black). Usual gait speed (m/s) over 20 minutes was assessed at baseline and over a 5-year follow-up. Results. Poorer performance in each cognitive task was cross-sectionally associated with slower gait independent of demographic and health characteristics. In longitudinal analyses, each 1 SD poorer performance in global function, verbal memory, and executive function was associated with 0.003–0.004 m/s greater gait speed decline per year (p =.03–.05) after adjustment for baseline gait speed, demographic, and health characteristics. Conclusions. In this well-functioning cohort, several cognitive tasks were associated with gait speed cross-sectionally and predicted longitudinal gait speed decline. These data are consistent with a shared pathology underlying cognitive and motor declines but do not suggest that specific executive cognitive deficits account for slowing of usual gait in aging. |
| doi_str_mv | 10.1093/gerona/glq111 |
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L. ; Rosano, C. ; Boudreau, R. M. ; Simonsick, E. M. ; Ferrucci, L. ; Sutton-Tyrrell, K. ; Hardy, S. E. ; Atkinson, H. H. ; Yaffe, K. ; Satterfield, S. ; Harris, T. B. ; Newman, A. B.</creator><creatorcontrib>Watson, N. L. ; Rosano, C. ; Boudreau, R. M. ; Simonsick, E. M. ; Ferrucci, L. ; Sutton-Tyrrell, K. ; Hardy, S. E. ; Atkinson, H. H. ; Yaffe, K. ; Satterfield, S. ; Harris, T. B. ; Newman, A. B. ; Health ABC Study ; for the Health ABC Study</creatorcontrib><description>Background. In community-dwelling older adults, global cognitive function predicts longitudinal gait speed decline. Few prospective studies have evaluated whether specific executive cognitive deficits in aging may account for gait slowing over time. Methods. Multiple cognitive tasks were administered at baseline in 909 participants in the Health, Aging, and Body Composition Study Cognitive Vitality Substudy (mean age 75.2 ± 2.8 years, 50.6% women, 48.4% black). Usual gait speed (m/s) over 20 minutes was assessed at baseline and over a 5-year follow-up. Results. Poorer performance in each cognitive task was cross-sectionally associated with slower gait independent of demographic and health characteristics. In longitudinal analyses, each 1 SD poorer performance in global function, verbal memory, and executive function was associated with 0.003–0.004 m/s greater gait speed decline per year (p =.03–.05) after adjustment for baseline gait speed, demographic, and health characteristics. Conclusions. In this well-functioning cohort, several cognitive tasks were associated with gait speed cross-sectionally and predicted longitudinal gait speed decline. These data are consistent with a shared pathology underlying cognitive and motor declines but do not suggest that specific executive cognitive deficits account for slowing of usual gait in aging.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glq111</identifier><identifier>PMID: 20581339</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Aging ; Aging - physiology ; Analysis of Variance ; Cognition & reasoning ; Cognitive function ; Cross-Sectional Studies ; Executive Function - physiology ; Female ; Gait - physiology ; Gait speed ; Gerontology ; Health Status ; Humans ; Journal of Gerontology: MEDICAL SCIENCES ; Linear Models ; Longitudinal Studies ; Male ; Memory ; Memory - physiology ; Neuropsychological Tests ; Older people ; Risk Factors ; Statistics, Nonparametric</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2010-10, Vol.65A (10), p.1093-1100</ispartof><rights>The Author 2010. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2010</rights><rights>Copyright Oxford University Press, UK Oct 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-d1eb3d26c1acc94c60498116ed5043b4c5a39c70a90242eea3b9a035defc25393</citedby><cites>FETCH-LOGICAL-c550t-d1eb3d26c1acc94c60498116ed5043b4c5a39c70a90242eea3b9a035defc25393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20581339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watson, N. L.</creatorcontrib><creatorcontrib>Rosano, C.</creatorcontrib><creatorcontrib>Boudreau, R. M.</creatorcontrib><creatorcontrib>Simonsick, E. M.</creatorcontrib><creatorcontrib>Ferrucci, L.</creatorcontrib><creatorcontrib>Sutton-Tyrrell, K.</creatorcontrib><creatorcontrib>Hardy, S. E.</creatorcontrib><creatorcontrib>Atkinson, H. H.</creatorcontrib><creatorcontrib>Yaffe, K.</creatorcontrib><creatorcontrib>Satterfield, S.</creatorcontrib><creatorcontrib>Harris, T. B.</creatorcontrib><creatorcontrib>Newman, A. B.</creatorcontrib><creatorcontrib>Health ABC Study</creatorcontrib><creatorcontrib>for the Health ABC Study</creatorcontrib><title>Executive Function, Memory, and Gait Speed Decline in Well-Functioning Older Adults</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Background. In community-dwelling older adults, global cognitive function predicts longitudinal gait speed decline. Few prospective studies have evaluated whether specific executive cognitive deficits in aging may account for gait slowing over time. Methods. Multiple cognitive tasks were administered at baseline in 909 participants in the Health, Aging, and Body Composition Study Cognitive Vitality Substudy (mean age 75.2 ± 2.8 years, 50.6% women, 48.4% black). Usual gait speed (m/s) over 20 minutes was assessed at baseline and over a 5-year follow-up. Results. Poorer performance in each cognitive task was cross-sectionally associated with slower gait independent of demographic and health characteristics. In longitudinal analyses, each 1 SD poorer performance in global function, verbal memory, and executive function was associated with 0.003–0.004 m/s greater gait speed decline per year (p =.03–.05) after adjustment for baseline gait speed, demographic, and health characteristics. Conclusions. In this well-functioning cohort, several cognitive tasks were associated with gait speed cross-sectionally and predicted longitudinal gait speed decline. These data are consistent with a shared pathology underlying cognitive and motor declines but do not suggest that specific executive cognitive deficits account for slowing of usual gait in aging.</description><subject>Aged</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Analysis of Variance</subject><subject>Cognition & reasoning</subject><subject>Cognitive function</subject><subject>Cross-Sectional Studies</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Gait - physiology</subject><subject>Gait speed</subject><subject>Gerontology</subject><subject>Health Status</subject><subject>Humans</subject><subject>Journal of Gerontology: MEDICAL SCIENCES</subject><subject>Linear Models</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Memory</subject><subject>Memory - physiology</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>Risk Factors</subject><subject>Statistics, Nonparametric</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PHDEMhqMKVCjlyBVFXOiBgWQyyUwuSIjPSos4bCtQL1E28S6B2WRJZhD8e4JmWbVc6ost-fFrWy9CO5QcUiLZ0Qxi8Ppo1j5RSr-gTVrzpuCM363lmtSy4ISIDfQtpQfyHrz8ijZKwhvKmNxE4_MXMH3nngFf9N50LvgDfA3zEF8PsPYWX2rX4fECwOIzMK3zgJ3Ht9C2xceA8zN801qI-MT2bZe-o_WpbhNsL_MW-n1x_uv0qhjdXP48PRkVhnPSFZbChNlSGKqNkZURpJINpQIsJxWbVIZrJk1NtCRlVQJoNpGaMG5hakrOJNtCx4Puop_MwRrwXdStWkQ31_FVBe3Uvx3v7tUsPKtSVpKxKgvsLwVieOohdWruksmvaQ-hT6rmnDZNU4lM7n0iH0Ifff4uQ0SSRvAmQ8UAmRhSijBdnUKJejdLDWapwazM7_59_4r-cCcDPwYg9Iv_ai13u9TBywrW8VGJmtVcXd39UYJdi3E9EoqyNzcfrvs</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Watson, N. L.</creator><creator>Rosano, C.</creator><creator>Boudreau, R. M.</creator><creator>Simonsick, E. M.</creator><creator>Ferrucci, L.</creator><creator>Sutton-Tyrrell, K.</creator><creator>Hardy, S. E.</creator><creator>Atkinson, H. H.</creator><creator>Yaffe, K.</creator><creator>Satterfield, S.</creator><creator>Harris, T. B.</creator><creator>Newman, A. B.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101001</creationdate><title>Executive Function, Memory, and Gait Speed Decline in Well-Functioning Older Adults</title><author>Watson, N. L. ; Rosano, C. ; Boudreau, R. M. ; Simonsick, E. M. ; Ferrucci, L. ; Sutton-Tyrrell, K. ; Hardy, S. E. ; Atkinson, H. H. ; Yaffe, K. ; Satterfield, S. ; Harris, T. 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B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-d1eb3d26c1acc94c60498116ed5043b4c5a39c70a90242eea3b9a035defc25393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Analysis of Variance</topic><topic>Cognition & reasoning</topic><topic>Cognitive function</topic><topic>Cross-Sectional Studies</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Gait - physiology</topic><topic>Gait speed</topic><topic>Gerontology</topic><topic>Health Status</topic><topic>Humans</topic><topic>Journal of Gerontology: MEDICAL SCIENCES</topic><topic>Linear Models</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Memory</topic><topic>Memory - physiology</topic><topic>Neuropsychological Tests</topic><topic>Older people</topic><topic>Risk Factors</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watson, N. L.</creatorcontrib><creatorcontrib>Rosano, C.</creatorcontrib><creatorcontrib>Boudreau, R. M.</creatorcontrib><creatorcontrib>Simonsick, E. M.</creatorcontrib><creatorcontrib>Ferrucci, L.</creatorcontrib><creatorcontrib>Sutton-Tyrrell, K.</creatorcontrib><creatorcontrib>Hardy, S. E.</creatorcontrib><creatorcontrib>Atkinson, H. H.</creatorcontrib><creatorcontrib>Yaffe, K.</creatorcontrib><creatorcontrib>Satterfield, S.</creatorcontrib><creatorcontrib>Harris, T. B.</creatorcontrib><creatorcontrib>Newman, A. B.</creatorcontrib><creatorcontrib>Health ABC Study</creatorcontrib><creatorcontrib>for the Health ABC Study</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watson, N. L.</au><au>Rosano, C.</au><au>Boudreau, R. M.</au><au>Simonsick, E. M.</au><au>Ferrucci, L.</au><au>Sutton-Tyrrell, K.</au><au>Hardy, S. E.</au><au>Atkinson, H. H.</au><au>Yaffe, K.</au><au>Satterfield, S.</au><au>Harris, T. B.</au><au>Newman, A. B.</au><aucorp>Health ABC Study</aucorp><aucorp>for the Health ABC Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Executive Function, Memory, and Gait Speed Decline in Well-Functioning Older Adults</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>65A</volume><issue>10</issue><spage>1093</spage><epage>1100</epage><pages>1093-1100</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Background. In community-dwelling older adults, global cognitive function predicts longitudinal gait speed decline. Few prospective studies have evaluated whether specific executive cognitive deficits in aging may account for gait slowing over time. Methods. Multiple cognitive tasks were administered at baseline in 909 participants in the Health, Aging, and Body Composition Study Cognitive Vitality Substudy (mean age 75.2 ± 2.8 years, 50.6% women, 48.4% black). Usual gait speed (m/s) over 20 minutes was assessed at baseline and over a 5-year follow-up. Results. Poorer performance in each cognitive task was cross-sectionally associated with slower gait independent of demographic and health characteristics. In longitudinal analyses, each 1 SD poorer performance in global function, verbal memory, and executive function was associated with 0.003–0.004 m/s greater gait speed decline per year (p =.03–.05) after adjustment for baseline gait speed, demographic, and health characteristics. Conclusions. In this well-functioning cohort, several cognitive tasks were associated with gait speed cross-sectionally and predicted longitudinal gait speed decline. These data are consistent with a shared pathology underlying cognitive and motor declines but do not suggest that specific executive cognitive deficits account for slowing of usual gait in aging.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>20581339</pmid><doi>10.1093/gerona/glq111</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aging Aging - physiology Analysis of Variance Cognition & reasoning Cognitive function Cross-Sectional Studies Executive Function - physiology Female Gait - physiology Gait speed Gerontology Health Status Humans Journal of Gerontology: MEDICAL SCIENCES Linear Models Longitudinal Studies Male Memory Memory - physiology Neuropsychological Tests Older people Risk Factors Statistics, Nonparametric |
| title | Executive Function, Memory, and Gait Speed Decline in Well-Functioning Older Adults |
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