Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries

Although dihydropyridines are widely used for the treatment of vasospasm, their effectiveness is questionable, suggesting that other voltage-dependent calcium channels (VDCCs) contribute to control of cerebrovascular tone. This study therefore investigated the role of dihydropyridine-insensitive VDC...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2010-06, Vol.30 (6), p.1226-1239
Hauptverfasser:	Kuo, Ivana Y, Ellis, Anthie, Seymour, Victoria AL, Sandow, Shaun L, Hill, Caryl E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels, L-Type - metabolism Calcium Channels, T-Type - metabolism Cell Membrane - metabolism Cell Membrane - ultrastructure Cerebral Arteries - metabolism Cerebral Arteries - ultrastructure Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Dihydropyridines - pharmacology Fundamental and applied biological sciences. Psychology Male Medical sciences Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - ultrastructure Neurology Original Rats Rats, Wistar Vascular diseases and vascular malformations of the nervous system Vasoconstriction - drug effects Vasoconstriction - physiology Vertebrates: nervous system and sense organs
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