Significance of host cell kinases in herpes simplex virus type 1 egress and lamin-associated protein disassembly from the nuclear lamina

Abstract The nuclear lamina is thought to be a steric barrier to the herpesvirus capsid. Disruption of the lamina accompanied by phosphorylation of lamina proteins is a conserved feature of herpesvirus infection. In HSV-1-infected cells, protein kinase C (PKC) alpha and delta isoforms are recruited...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2010-10, Vol.406 (1), p.127-137
Hauptverfasser:	Leach, Natalie R, Roller, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Base Sequence Capsid - drug effects Capsid - physiology Capsid - ultrastructure Cell Line Cercopithecus aethiops CHEMICAL REACTIONS DISEASES DNA Primers - genetics Emerin ENZYMES GROWTH HERPES SIMPLEX Herpes simplex virus 1 Herpesvirus Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - genetics Herpesvirus 1, Human - physiology Herpesvirus 1, Human - ultrastructure HOST Host-Pathogen Interactions - drug effects Host-Pathogen Interactions - physiology HSV-1 Humans Infectious Disease INFECTIOUS DISEASES Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - physiology MICROORGANISMS Microscopy, Electron, Transmission Models, Biological Nuclear egress Nuclear lamina Nuclear Lamina - drug effects Nuclear Lamina - enzymology Nuclear Lamina - virology Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - physiology ORGANIC COMPOUNDS PARASITES PHOSPHORUS-GROUP TRANSFERASES PHOSPHORYLATION PHOSPHOTRANSFERASES Protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Protein Kinase Inhibitors - pharmacology PROTEINS SKIN DISEASES TRANSFERASES Vero Cells VIRAL DISEASES Virus Assembly - drug effects Virus Assembly - physiology Virus Release - drug effects Virus Release - physiology Virus Replication - drug effects Virus Replication - physiology VIRUSES
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