Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctions

Background Gap junctions are potential targets for pharmacologic intervention. We previously developed a series of peptide sequences that prevent closure of connexin43 (Cx43) channels, bind to cardiac Cx43, and prevent acidification-induced uncoupling of cardiac gap junctions. Objective The purpose...

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Veröffentlicht in:	Heart rhythm 2010-10, Vol.7 (10), p.1491-1498
Hauptverfasser:	Verma, Vandana, PhD, Larsen, Bjarne Due, PhD, Coombs, Wanda, BS, Lin, Xianming, PhD, Sarrou, Eliana, BS, Taffet, Steven M., PhD, Delmar, Mario, MD, PhD, FHRS
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmia Cardiovascular Carrier Proteins - pharmacology Cells, Cultured Connexin 43 Connexin 43 - drug effects Connexin 43 - metabolism Drug Design Gap junction Gap Junctions - drug effects Gap Junctions - physiology Hydrogen-Ion Concentration Mice Models, Molecular Myocytes, Cardiac - metabolism Myocytes, Cardiac - physiology Octanols - pharmacology Oligopeptides - chemical synthesis Oligopeptides - pharmacology Patch-Clamp Techniques Peptidomimetics - chemical synthesis Peptidomimetics - chemistry Peptidomimetics - pharmacology Rats
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