Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

The initiation of eukaryotic DNA replication is regulated by three protein kinase classes: cyclin-dependent kinases (CDK), Dbf4-dependent kinase (DDK) and the DNA damage checkpoint kinases. CDK phosphorylation of two key initiation factors, Sld2 and Sld3, promotes essential interactions with Dpb11 (...

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Veröffentlicht in:	Nature (London) 2010-09, Vol.467 (7314), p.474-478
Hauptverfasser:	Diffley, John F. X, Zegerman, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/151 631/337/458/1733 631/80/86/2371 Arrays Biological and medical sciences Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell cycle, cell proliferation Cell physiology Checkpoint Kinase 2 Cyclin-Dependent Kinases - metabolism Deoxyribonucleic acid DNA DNA Damage DNA replication DNA Replication - physiology DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E coli Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Kinases letter Molecular and cellular biology multidisciplinary Mutation Observations Peptides Phosphorylation Properties Protein kinases Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Replication Origin - physiology S Phase - physiology Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Science Science (multidisciplinary) Substrate Specificity
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