Lower respiratory tract infections among human immunodeficiency virus-exposed, uninfected infants
Summary Objectives To evaluate whether maternal HIV disease severity during pregnancy is associated with an increased likelihood of lower respiratory tract infections (LRTIs) in HIV-exposed, uninfected infants. Methods HIV-exposed, uninfected, singleton, term infants enrolled in the NISDI Perinatal...
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| Veröffentlicht in: | International journal of infectious diseases 2010-09, Vol.14, p.e176-e182 |
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| creator | Mussi-Pinhata, Marisa M Motta, Fabrizio Freimanis-Hance, Laura de Souza, Ricardo Szyld, Edgardo Succi, Regina C.M Christie, Celia D.C Rolon, Maria J Ceriotto, Mariana Read, Jennifer S |
| description | Summary Objectives To evaluate whether maternal HIV disease severity during pregnancy is associated with an increased likelihood of lower respiratory tract infections (LRTIs) in HIV-exposed, uninfected infants. Methods HIV-exposed, uninfected, singleton, term infants enrolled in the NISDI Perinatal Study, with birth weight >2500 g were followed from birth until 6 months of age. LRTI diagnoses, hospitalizations, and associated factors were assessed. Results Of 547 infants, 103 (18.8%) experienced 116 episodes of LRTI (incidence = 0.84 LRTIs/100 child-weeks). Most (81%) episodes were bronchiolitis. Forty-nine (9.0%) infants were hospitalized at least once with an LRTI. There were 53 hospitalizations (45.7%) for 116 LRTI episodes. None of these infants were breastfed. The odds of LRTI in infants whose mothers had CD4% |
| doi_str_mv | 10.1016/j.ijid.2010.01.006 |
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Methods HIV-exposed, uninfected, singleton, term infants enrolled in the NISDI Perinatal Study, with birth weight >2500 g were followed from birth until 6 months of age. LRTI diagnoses, hospitalizations, and associated factors were assessed. Results Of 547 infants, 103 (18.8%) experienced 116 episodes of LRTI (incidence = 0.84 LRTIs/100 child-weeks). Most (81%) episodes were bronchiolitis. Forty-nine (9.0%) infants were hospitalized at least once with an LRTI. There were 53 hospitalizations (45.7%) for 116 LRTI episodes. None of these infants were breastfed. The odds of LRTI in infants whose mothers had CD4% <14 at enrollment were 4.4 times those of infants whose mothers had CD4% ≥29 ( p = 0.003). The odds of LRTI in infants with a CD4+ count (cells/mm3 ) <750 at hospital discharge were 16.0 times those of infants with CD4+ ≥750 ( p = 0.002). Maternal CD4+ decline and infant hemoglobin at the 6–12 week visit were associated with infant LRTIs after 6–12 weeks and before 6 months of age. Conclusions Acute bronchiolitis is common and frequently severe among HIV-exposed, uninfected infants aged 6 months or less. Lower maternal and infant CD4+ values were associated with a higher risk of infant LRTIs. Further understanding of the immunological mechanisms of severe LRTIs is needed.</description><identifier>ISSN: 1201-9712</identifier><identifier>EISSN: 1878-3511</identifier><identifier>DOI: 10.1016/j.ijid.2010.01.006</identifier><identifier>PMID: 20452798</identifier><language>eng</language><publisher>Canada: Elsevier Ltd</publisher><subject>Adult ; Argentina ; Brazil ; Bronchiolitis - etiology ; Bronchiolitis - immunology ; CD4 Lymphocyte Count ; Cohort Studies ; Female ; HIV Infections - immunology ; HIV Infections - transmission ; HIV-exposed ; Humans ; Infancy ; Infant ; Infant, Newborn ; Infections ; Infectious Disease ; Infectious Disease Transmission, Vertical ; Latin America ; Male ; Pregnancy ; Pregnancy Complications, Infectious - immunology ; Prenatal Exposure Delayed Effects - immunology ; Prospective Studies ; Pulmonary/Respiratory ; Respiratory Tract Infections - etiology ; Respiratory Tract Infections - immunology ; Risk Factors</subject><ispartof>International journal of infectious diseases, 2010-09, Vol.14, p.e176-e182</ispartof><rights>International Society for Infectious Diseases</rights><rights>2010 International Society for Infectious Diseases</rights><rights>Copyright © 2010 International Society for Infectious Diseases. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-cda8ca697e6a5f63f9cebaf1b5a27f8b1262d78d7933bd9075e3967ffe1cef53</citedby><cites>FETCH-LOGICAL-c509t-cda8ca697e6a5f63f9cebaf1b5a27f8b1262d78d7933bd9075e3967ffe1cef53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1201971210023325$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,860,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20452798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mussi-Pinhata, Marisa M</creatorcontrib><creatorcontrib>Motta, Fabrizio</creatorcontrib><creatorcontrib>Freimanis-Hance, Laura</creatorcontrib><creatorcontrib>de Souza, Ricardo</creatorcontrib><creatorcontrib>Szyld, Edgardo</creatorcontrib><creatorcontrib>Succi, Regina C.M</creatorcontrib><creatorcontrib>Christie, Celia D.C</creatorcontrib><creatorcontrib>Rolon, Maria J</creatorcontrib><creatorcontrib>Ceriotto, Mariana</creatorcontrib><creatorcontrib>Read, Jennifer S</creatorcontrib><creatorcontrib>for the NISDI Perinatal Study Group</creatorcontrib><creatorcontrib>NISDI Perinatal Study Group</creatorcontrib><title>Lower respiratory tract infections among human immunodeficiency virus-exposed, uninfected infants</title><title>International journal of infectious diseases</title><addtitle>Int J Infect Dis</addtitle><description>Summary Objectives To evaluate whether maternal HIV disease severity during pregnancy is associated with an increased likelihood of lower respiratory tract infections (LRTIs) in HIV-exposed, uninfected infants. Methods HIV-exposed, uninfected, singleton, term infants enrolled in the NISDI Perinatal Study, with birth weight >2500 g were followed from birth until 6 months of age. LRTI diagnoses, hospitalizations, and associated factors were assessed. Results Of 547 infants, 103 (18.8%) experienced 116 episodes of LRTI (incidence = 0.84 LRTIs/100 child-weeks). Most (81%) episodes were bronchiolitis. Forty-nine (9.0%) infants were hospitalized at least once with an LRTI. There were 53 hospitalizations (45.7%) for 116 LRTI episodes. None of these infants were breastfed. The odds of LRTI in infants whose mothers had CD4% <14 at enrollment were 4.4 times those of infants whose mothers had CD4% ≥29 ( p = 0.003). The odds of LRTI in infants with a CD4+ count (cells/mm3 ) <750 at hospital discharge were 16.0 times those of infants with CD4+ ≥750 ( p = 0.002). Maternal CD4+ decline and infant hemoglobin at the 6–12 week visit were associated with infant LRTIs after 6–12 weeks and before 6 months of age. Conclusions Acute bronchiolitis is common and frequently severe among HIV-exposed, uninfected infants aged 6 months or less. Lower maternal and infant CD4+ values were associated with a higher risk of infant LRTIs. Further understanding of the immunological mechanisms of severe LRTIs is needed.</description><subject>Adult</subject><subject>Argentina</subject><subject>Brazil</subject><subject>Bronchiolitis - etiology</subject><subject>Bronchiolitis - immunology</subject><subject>CD4 Lymphocyte Count</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - transmission</subject><subject>HIV-exposed</subject><subject>Humans</subject><subject>Infancy</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Infectious Disease</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Latin America</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>Prenatal Exposure Delayed Effects - immunology</subject><subject>Prospective Studies</subject><subject>Pulmonary/Respiratory</subject><subject>Respiratory Tract Infections - etiology</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Risk Factors</subject><issn>1201-9712</issn><issn>1878-3511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk1v1DAQjRCIlsIf4IBy40IW29n4Q0KVUMWXtBIHeh859rh1SOzFThb23-OwpQIOnGx53nvjeW-q6jklG0oofz1s_ODthpHyQOiGEP6gOqdSyKbtKH1Y7qXUKEHZWfUk54EQsuVcPq7OGNl2TCh5Xuld_I6pTpj3Puk5pmM9J23m2geHZvYx5FpPMdzUt8ukQ-2naQnRovPGYzDH-uDTkhv8sY8Z7at6CSci2lVBhzk_rR45PWZ8dndeVNfv311ffWx2nz98unq7a0xH1NwYq6XRXAnkunO8dcpgrx3tO82Ekz1lnFkhrVBt21tFRIet4sI5pAZd115UlyfZ_dJPaA2GMscI--QnnY4QtYe_K8Hfwk08AFNb0UlVBF7eCaT4bcE8w-SzwXHUAeOSQXRKilawtRU7IU2KOSd0910ogTUZGGBNBtZkgFAoyRTSiz__d0_5HUUBvDkBsJh08Jgg_7IYrU_FULDR_1__8h-6GX3wRo9f8Yh5iEsKxX6gkBkQ-LLuxroalBDWtmWqn3y5uPE</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Mussi-Pinhata, Marisa M</creator><creator>Motta, Fabrizio</creator><creator>Freimanis-Hance, Laura</creator><creator>de Souza, Ricardo</creator><creator>Szyld, Edgardo</creator><creator>Succi, Regina C.M</creator><creator>Christie, Celia D.C</creator><creator>Rolon, Maria J</creator><creator>Ceriotto, Mariana</creator><creator>Read, Jennifer S</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Lower respiratory tract infections among human immunodeficiency virus-exposed, uninfected infants</title><author>Mussi-Pinhata, Marisa M ; Motta, Fabrizio ; Freimanis-Hance, Laura ; de Souza, Ricardo ; Szyld, Edgardo ; Succi, Regina C.M ; Christie, Celia D.C ; Rolon, Maria J ; Ceriotto, Mariana ; Read, Jennifer S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-cda8ca697e6a5f63f9cebaf1b5a27f8b1262d78d7933bd9075e3967ffe1cef53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Argentina</topic><topic>Brazil</topic><topic>Bronchiolitis - etiology</topic><topic>Bronchiolitis - immunology</topic><topic>CD4 Lymphocyte Count</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - transmission</topic><topic>HIV-exposed</topic><topic>Humans</topic><topic>Infancy</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Infectious Disease</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Latin America</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - immunology</topic><topic>Prenatal Exposure Delayed Effects - immunology</topic><topic>Prospective Studies</topic><topic>Pulmonary/Respiratory</topic><topic>Respiratory Tract Infections - etiology</topic><topic>Respiratory Tract Infections - immunology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mussi-Pinhata, Marisa M</creatorcontrib><creatorcontrib>Motta, Fabrizio</creatorcontrib><creatorcontrib>Freimanis-Hance, Laura</creatorcontrib><creatorcontrib>de Souza, Ricardo</creatorcontrib><creatorcontrib>Szyld, Edgardo</creatorcontrib><creatorcontrib>Succi, Regina C.M</creatorcontrib><creatorcontrib>Christie, Celia D.C</creatorcontrib><creatorcontrib>Rolon, Maria J</creatorcontrib><creatorcontrib>Ceriotto, Mariana</creatorcontrib><creatorcontrib>Read, Jennifer S</creatorcontrib><creatorcontrib>for the NISDI Perinatal Study Group</creatorcontrib><creatorcontrib>NISDI Perinatal Study Group</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mussi-Pinhata, Marisa M</au><au>Motta, Fabrizio</au><au>Freimanis-Hance, Laura</au><au>de Souza, Ricardo</au><au>Szyld, Edgardo</au><au>Succi, Regina C.M</au><au>Christie, Celia D.C</au><au>Rolon, Maria J</au><au>Ceriotto, Mariana</au><au>Read, Jennifer S</au><aucorp>for the NISDI Perinatal Study Group</aucorp><aucorp>NISDI Perinatal Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower respiratory tract infections among human immunodeficiency virus-exposed, uninfected infants</atitle><jtitle>International journal of infectious diseases</jtitle><addtitle>Int J Infect Dis</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>14</volume><spage>e176</spage><epage>e182</epage><pages>e176-e182</pages><issn>1201-9712</issn><eissn>1878-3511</eissn><abstract>Summary Objectives To evaluate whether maternal HIV disease severity during pregnancy is associated with an increased likelihood of lower respiratory tract infections (LRTIs) in HIV-exposed, uninfected infants. Methods HIV-exposed, uninfected, singleton, term infants enrolled in the NISDI Perinatal Study, with birth weight >2500 g were followed from birth until 6 months of age. LRTI diagnoses, hospitalizations, and associated factors were assessed. Results Of 547 infants, 103 (18.8%) experienced 116 episodes of LRTI (incidence = 0.84 LRTIs/100 child-weeks). Most (81%) episodes were bronchiolitis. Forty-nine (9.0%) infants were hospitalized at least once with an LRTI. There were 53 hospitalizations (45.7%) for 116 LRTI episodes. None of these infants were breastfed. The odds of LRTI in infants whose mothers had CD4% <14 at enrollment were 4.4 times those of infants whose mothers had CD4% ≥29 ( p = 0.003). The odds of LRTI in infants with a CD4+ count (cells/mm3 ) <750 at hospital discharge were 16.0 times those of infants with CD4+ ≥750 ( p = 0.002). Maternal CD4+ decline and infant hemoglobin at the 6–12 week visit were associated with infant LRTIs after 6–12 weeks and before 6 months of age. Conclusions Acute bronchiolitis is common and frequently severe among HIV-exposed, uninfected infants aged 6 months or less. Lower maternal and infant CD4+ values were associated with a higher risk of infant LRTIs. Further understanding of the immunological mechanisms of severe LRTIs is needed.</abstract><cop>Canada</cop><pub>Elsevier Ltd</pub><pmid>20452798</pmid><doi>10.1016/j.ijid.2010.01.006</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Argentina Brazil Bronchiolitis - etiology Bronchiolitis - immunology CD4 Lymphocyte Count Cohort Studies Female HIV Infections - immunology HIV Infections - transmission HIV-exposed Humans Infancy Infant Infant, Newborn Infections Infectious Disease Infectious Disease Transmission, Vertical Latin America Male Pregnancy Pregnancy Complications, Infectious - immunology Prenatal Exposure Delayed Effects - immunology Prospective Studies Pulmonary/Respiratory Respiratory Tract Infections - etiology Respiratory Tract Infections - immunology Risk Factors |
| title | Lower respiratory tract infections among human immunodeficiency virus-exposed, uninfected infants |
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