Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass

Aims/hypothesis Prolonged exposure of pancreatic beta cells to excessive levels of glucose and fatty acids, referred to as glucolipotoxicity, is postulated to contribute to impaired glucose homeostasis in patients with type 2 diabetes. However, the relative contribution of defective beta cell functi...

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Veröffentlicht in:	Diabetologia 2010-11, Vol.53 (11), p.2369-2379
Hauptverfasser:	Fontés, G., Zarrouki, B., Hagman, D. K., Latour, M. G., Semache, M., Roskens, V., Moore, P. C., Prentki, M., Rhodes, C. J., Jetton, T. L., Poitout, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Cell Proliferation - drug effects Cells, Cultured Diabetes. Impaired glucose tolerance Disorders of blood lipids. Hyperlipoproteinemia Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids - toxicity Glucose - toxicity Human Physiology Immunohistochemistry In Vitro Techniques Insulin - metabolism Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Proinsulin - metabolism Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction
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