Bone and glucose metabolism: A two-way street
Evidence from rodent models indicates that undercarboxylated osteocalcin (ucOC), a product of osteoblasts, is a hormone affecting insulin production by the pancreas and insulin sensitivity in peripheral tissues, at least in part through enhanced secretion of adiponectin from adipocytes. Clinical res...
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| Veröffentlicht in: | Archives of biochemistry and biophysics 2010-11, Vol.503 (1), p.2-10 |
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| creator | Motyl, Katherine J. McCabe, Laura R. Schwartz, Ann V. |
| description | Evidence from rodent models indicates that undercarboxylated osteocalcin (ucOC), a product of osteoblasts, is a hormone affecting insulin production by the pancreas and insulin sensitivity in peripheral tissues, at least in part through enhanced secretion of adiponectin from adipocytes. Clinical research to test whether this relationship is found in humans is just beginning to emerge. Cross-sectional studies confirm associations between total osteocalcin (OC), ucOC and glucose metabolism but cannot distinguish causality. To date, longitudinal studies have not provided a consistent picture of the effects of ucOC or OC on fasting glucose and insulin sensitivity. Further exploration into the physiological and mechanistic effects of ucOC and OC, in rodent models and clinical studies, is necessary to determine to what extent the skeleton regulates energy metabolism in humans.
► Bone effects on glucose metabolism in mice and humans. ► Undercarboxylated osteocalcin (ucOC) promotes insulin secretion and sensitivity in mice. ► Lower OC and insulin resistance associated in cross-sectional clinical studies. ► Longitudinal studies needed to determine if OC affects glucose metabolism in humans. |
| doi_str_mv | 10.1016/j.abb.2010.07.030 |
| format | Article |
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► Bone effects on glucose metabolism in mice and humans. ► Undercarboxylated osteocalcin (ucOC) promotes insulin secretion and sensitivity in mice. ► Lower OC and insulin resistance associated in cross-sectional clinical studies. ► Longitudinal studies needed to determine if OC affects glucose metabolism in humans.</description><subject>Animals</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - physiopathology</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Insulin sensitivity</subject><subject>Models, Animal</subject><subject>Osteocalcin - metabolism</subject><subject>Undercarboxylated osteocalcin</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP3TAQRq2qqNxCf0A3VXZd5XYmcfxopUqA-kBCYgNry4-B-iqJwc4F8e9rdCmim3ZljXzm08wcxt4jrBFQfNqsrXPrDmoNcg09vGIrBC1a6BV_zVYA0LdaCdxnb0vZACBy0b1h-x0I1XUKV6w9TjM1dg7N9bj1qVAz0WJdGmOZPjdHzXKf2nv70JQlEy2HbO_KjoXePb0H7PL7t4uTn-3Z-Y_Tk6Oz1g9cLa3sIFjtXfCOcz8Epb0KiiRKQhoER6U59FIF7ZS0zjt0kpQgNQitpYP-gH3d5d5s3UTB07xkO5qbHCebH0yy0fz9M8df5jrdmU5zofhQAz4-BeR0u6WymCkWT-NoZ0rbYjQq4KIe8b-kHAaUOCheSdyRPqdSMl09z4NgHn2Yjak-zKMPA9JUH7Xnw8tFnjv-CKjAlx1A9Zx3kbIpPtLsKcRMfjEhxX_E_wbSBpoq</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Motyl, Katherine J.</creator><creator>McCabe, Laura R.</creator><creator>Schwartz, Ann V.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>5PM</scope></search><sort><creationdate>20101101</creationdate><title>Bone and glucose metabolism: A two-way street</title><author>Motyl, Katherine J. ; McCabe, Laura R. ; Schwartz, Ann V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-720da9cbdcb44c5d89c8d8e717e1e56418940378d9b87abcb1b7e86e856997b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - metabolism</topic><topic>Bone and Bones - physiopathology</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Insulin sensitivity</topic><topic>Models, Animal</topic><topic>Osteocalcin - metabolism</topic><topic>Undercarboxylated osteocalcin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motyl, Katherine J.</creatorcontrib><creatorcontrib>McCabe, Laura R.</creatorcontrib><creatorcontrib>Schwartz, Ann V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motyl, Katherine J.</au><au>McCabe, Laura R.</au><au>Schwartz, Ann V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone and glucose metabolism: A two-way street</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>503</volume><issue>1</issue><spage>2</spage><epage>10</epage><pages>2-10</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>Evidence from rodent models indicates that undercarboxylated osteocalcin (ucOC), a product of osteoblasts, is a hormone affecting insulin production by the pancreas and insulin sensitivity in peripheral tissues, at least in part through enhanced secretion of adiponectin from adipocytes. 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► Bone effects on glucose metabolism in mice and humans. ► Undercarboxylated osteocalcin (ucOC) promotes insulin secretion and sensitivity in mice. ► Lower OC and insulin resistance associated in cross-sectional clinical studies. ► Longitudinal studies needed to determine if OC affects glucose metabolism in humans.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20682281</pmid><doi>10.1016/j.abb.2010.07.030</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of biochemistry and biophysics, 2010-11, Vol.503 (1), p.2-10 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Bone and Bones - drug effects Bone and Bones - metabolism Bone and Bones - physiopathology Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Glucose - metabolism Humans Insulin sensitivity Models, Animal Osteocalcin - metabolism Undercarboxylated osteocalcin |
| title | Bone and glucose metabolism: A two-way street |
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