Tilapia Hepcidin 2-3 Peptide Modulates Lipopolysaccharide-induced Cytokines and Inhibits Tumor Necrosis Factor-α through Cyclooxygenase-2 and Phosphodiesterase 4D

The antimicrobial peptide, tilapia hepcidin (TH) 2-3, belongs to the hepcidin family, and its antibacterial function has been reported. Here, we examined the TH2-3-mediated regulation of proinflammatory cytokines in bacterial endotoxin lipopolysaccharide (LPS)-stimulated mouse macrophages. The prese...

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Veröffentlicht in:	The Journal of biological chemistry 2010-10, Vol.285 (40), p.30577-30586
Hauptverfasser:	Rajanbabu, Venugopal, Pan, Chieh-Yu, Lee, Shang-Chun, Lin, Wei-Ju, Lin, Ching-Chun, Li, Chung-Leung, Chen, Jyh-Yih
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - pharmacology Antimicrobial Peptides Cell Line Cellular Immune Response Cyclic AMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Cyclooxygenase (COX) Pathway Cyclooxygenase 2 - metabolism Endotoxin Fish Proteins - pharmacology Gene Regulation Hepcidins Immunology Interleukin-1alpha - metabolism Interleukin-1beta - metabolism Interleukin-6 - metabolism Lipopolysaccharides - pharmacology Macrophages - metabolism Mice Mitogen-Activated Protein Kinase 3 - metabolism NF-kappa B p52 Subunit - metabolism Signal Transduction Tilapia Transcription Factor RelA - metabolism Tumor Necrosis Factor-alpha - metabolism
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