Cys Palmitoylation of the β Subunit Modulates Gating of the Epithelial Sodium Channel

The epithelial Na+ channel (ENaC) is comprised of three homologous subunits (α, β, and γ) that have a similar topology with two transmembrane domains, a large extracellular region, and cytoplasmic N and C termini. Although ENaC activity is regulated by a number of factors, palmitoylation of its cyto...

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Veröffentlicht in:	The Journal of biological chemistry 2010-10, Vol.285 (40), p.30453-30462
Hauptverfasser:	Mueller, Gunhild M., Maarouf, Ahmad B., Kinlough, Carol L., Sheng, Nan, Kashlan, Ossama B., Okumura, Sora, Luthy, Sarah, Kleyman, Thomas R., Hughey, Rebecca P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - pharmacology Amino Acid Substitution Animals Cell Line Cell Membrane - metabolism Channel Gating Computer Simulation Dogs ENaC Epithelial Sodium Channel Epithelial Sodium Channels - genetics Epithelial Sodium Channels - metabolism Intracellular Trafficking Ion Channel Gating - physiology Ion Channels Lipoylation - physiology Membrane Biology Mice Models, Molecular Mutation Mutation, Missense Oocytes Protein Palmitoylation Protein Structure, Secondary Protein Structure, Tertiary Protein Transport - physiology Sodium - metabolism Sodium Channel Blockers - pharmacology Sodium Channels Sodium Transport Xenopus laevis
Online-Zugang:	Volltext
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