Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats

We investigated whether non-abortive maternal infections would compromise fetal brain development and alter hypothalamic-pituitary-adrenocortical (HPA) axis functioning when adult. To study putative teratogenic effects of a T cell-mediated immune response versus an endotoxic challenge, 10-d-pregnant...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of clinical investigation 1994-06, Vol.93 (6), p.2600-2607
Hauptverfasser:	Reul, J M, Stec, I, Wiegers, G J, Labeur, M S, Linthorst, A C, Arzt, E, Holsboer, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - embryology Erythrocytes - immunology Female Humans Hypothalamo-Hypophyseal System - physiology Lipopolysaccharides - toxicity Male Pituitary-Adrenal System - physiology Pregnancy Pregnancy, Animal - immunology Rats Rats, Wistar Receptors, Steroid - analysis T-Lymphocytes - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!