Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors a 13-exon gene, pfcrt, having point mutations that associate completely with CQR in parasite lines from Asia, Africa, and South...

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Veröffentlicht in:	Molecular cell 2000-10, Vol.6 (4), p.861-871
Hauptverfasser:	Fidock, David A., Nomura, Takashi, Talley, Angela K., Cooper, Roland A., Dzekunov, Sergey M., Ferdig, Michael T., Ursos, Lyann M.B., bir Singh Sidhu, Amar, Naudé, Bronwen, Deitsch, Kirk W., Su, Xin-zhuan, Wootton, John C., Roepe, Paul D., Wellems, Thomas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Animals, Genetically Modified Chloroquine - pharmacology chromosome 7 Digestive System - metabolism Drug Resistance Exons hematin Humans Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Transport Proteins Molecular Sequence Data Mutagenesis, Site-Directed pfcrt gene Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Polymerase Chain Reaction Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Tetrahydrofolate Dehydrogenase - genetics Transfection Vacuoles - physiology verapamil Verapamil - pharmacology
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