The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

The ribosome is able to monitor the structure of the nascent peptide and can stall in response to specific peptide sequences. Such programmed stalling is used for the regulation of gene expression. The molecular mechanisms of the nascent‐peptide recognition and ribosome stalling are unknown. We iden...

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Veröffentlicht in:	The EMBO journal 2010-09, Vol.29 (18), p.3108-3117
Hauptverfasser:	Vázquez-Laslop, Nora, Ramu, Haripriya, Klepacki, Dorota, Kannan, Krishna, Mankin, Alexander S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibiotic resistance Bacterial Proteins - genetics Base Sequence Cellular biology EMBO31 EMBO36 erythromycin Gene expression Gene Expression Regulation - physiology Methylation Molecular biology Molecular Sequence Data Mutation nascent peptide Peptide Fragments - metabolism Peptides Protein Biosynthesis Ribonucleic acid ribosome Ribosomes - physiology RNA RNA, Bacterial - physiology RNA, Ribosomal - physiology rRNA Signal transduction translation
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