Telomere capping in non-dividing yeast cells requires Yku and Rap1

The assembly of a protective cap onto the telomeres of eukaryotic chromosomes suppresses genomic instability through inhibition of DNA repair activities that normally process accidental DNA breaks. We show here that the essential Cdc13–Stn1–Ten1 complex is entirely dispensable for telomere protectio...

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Veröffentlicht in:	The EMBO journal 2010-09, Vol.29 (17), p.3007-3019
Hauptverfasser:	Vodenicharov, Momchil D, Laterreur, Nancy, Wellinger, Raymund J
Format:	Artikel
Sprache:	eng
Schlagworte:	cell cycle Cell Cycle Proteins - metabolism Cellular biology Chromosomal Proteins, Non-Histone - metabolism chromosome capping Chromosomes Chromosomes, Fungal - metabolism Degradation Deoxyribonucleic acid DNA DNA repair DNA, Fungal - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism EMBO06 EMBO13 Gene Knockout Techniques genome instability Genomics Inactivation Microbial Viability Molecular biology resting cells Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Telomere - metabolism Telomere-Binding Proteins - metabolism telomeres Transcription Factors - metabolism Yeasts
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