Differentiation therapy of leukemia: 3 decades of development

A characteristic feature of leukemia cells is a blockade of differentiation at a distinct stage in cellular maturation. In the 1970s and 1980s, studies demonstrating the capabilities of certain chemicals to induce differentiation of hematopoietic cell lines fostered the concept of treating leukemia...

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Veröffentlicht in:	Blood 2009-04, Vol.113 (16), p.3655-3665
Hauptverfasser:	Nowak, Daniel, Stewart, Daphne, Koeffler, H. Phillip
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - history Antineoplastic Agents - therapeutic use Biological and medical sciences Cell Differentiation - drug effects Epigenesis, Genetic - drug effects Hematologic and hematopoietic diseases History, 20th Century History, 21st Century Humans Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - history Leukemia, Promyelocytic, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neoplasm Proteins - agonists Neoplasm Proteins - metabolism Review Transcription Factors - metabolism
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