Activation and Specificity of Human Caspase-10

Two apical caspases, caspase-8 and -10, are involved in the extrinsic death receptor pathway in humans, but it is mainly caspase-8 in its apoptotic and nonapoptotic functions that has been an intense research focus. In this study we concentrate on caspase-10, its mechanism of activation, and the rol...

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Veröffentlicht in:	Biochemistry (Easton) 2010-09, Vol.49 (38), p.8307-8315
Hauptverfasser:	Wachmann, Katherine, Pop, Cristina, van Raam, Bram J, Drag, Marcin, Mace, Peter D, Snipas, Scott J, Zmasek, Christian, Schwarzenbacher, Robert, Salvesen, Guy S, Riedl, Stefan J
Format:	Artikel
Sprache:	eng
Schlagworte:	BH3 Interacting Domain Death Agonist Protein - metabolism Caspase 10 - biosynthesis Dimerization Endopeptidases - metabolism Enzyme Activation Humans Substrate Specificity
Online-Zugang:	Volltext
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