Evidence for Physical Association of Mitochondrial Fatty Acid Oxidation and Oxidative Phosphorylation Complexes

Fatty acid β-oxidation (FAO) and oxidative phosphorylation (OXPHOS) are key pathways involved in cellular energetics. Reducing equivalents from FAO enter OXPHOS at the level of complexes I and III. Genetic disorders of FAO and OXPHOS are among the most frequent inborn errors of metabolism. Patients...

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Veröffentlicht in:	The Journal of biological chemistry 2010-09, Vol.285 (39), p.29834-29841
Hauptverfasser:	Wang, Yudong, Mohsen, Al-Walid, Mihalik, Stephanie J., Goetzman, Eric S., Vockley, Jerry
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Dehydrogenases Animals Bioenergetics Cytochromes c - genetics Cytochromes c - metabolism Electron Transport Complex I - genetics Electron Transport Complex I - metabolism Electron Transport Complex III - genetics Electron Transport Complex III - metabolism Energy Metabolism Enzyme Mechanisms Fatty Acid Metabolism Fatty Acid Oxidation Fatty Acids - genetics Fatty Acids - metabolism Metabolic Channeling Metabolism Metabolism, Inborn Errors - enzymology Metabolism, Inborn Errors - genetics Mitochondria, Liver - genetics Mitochondria, Liver - metabolism Mitochondrial Metabolism Oxidation-Reduction Oxidative Phosphorylation Rats Respiratory Chain Supercomplexes
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