Brain regional lesion burden and impaired mobility in the elderly
Abstract This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects ≥75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, b...
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| Veröffentlicht in: | Neurobiology of aging 2011-04, Vol.32 (4), p.646-654 |
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| creator | Moscufo, Nicola Guttmann, Charles R.G Meier, Dominik Csapo, Istvan Hildenbrand, Peter G Healy, Brian C Schmidt, Julia A Wolfson, Leslie |
| description | Abstract This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects ≥75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the splenium of corpus callosum (SCC) demonstrated the highest correlation particularly with walking speed ( r = 0.4, p < 10−4 ), and in logistic regression it was the best regional predictor of low mobility performance. We also found that independent of mobility, corona radiata has the largest lesion burden with anterior (ACR) and posterior (PCR) aspects being the most frequently affected. The results suggest that compromised inter-hemispheric integration of visuospatial information through the SCC plays an important role in mobility impairment in the elderly. The relatively high lesion susceptibility of ACR and PCR in all subjects may obscure the importance of these lesions in mobility impairment. |
| doi_str_mv | 10.1016/j.neurobiolaging.2009.04.010 |
| format | Article |
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We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the splenium of corpus callosum (SCC) demonstrated the highest correlation particularly with walking speed ( r = 0.4, p < 10−4 ), and in logistic regression it was the best regional predictor of low mobility performance. We also found that independent of mobility, corona radiata has the largest lesion burden with anterior (ACR) and posterior (PCR) aspects being the most frequently affected. The results suggest that compromised inter-hemispheric integration of visuospatial information through the SCC plays an important role in mobility impairment in the elderly. The relatively high lesion susceptibility of ACR and PCR in all subjects may obscure the importance of these lesions in mobility impairment.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2009.04.010</identifier><identifier>PMID: 19428145</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Aging - pathology ; Aging - physiology ; Biological and medical sciences ; Brain ; Brain - pathology ; Corona radiata ; Development. Senescence. Regeneration. Transplantation ; Female ; Fundamental and applied biological sciences. Psychology ; Gait - physiology ; Humans ; Image Processing, Computer-Assisted ; Internal Medicine ; Logistic Models ; Magnetic Resonance Imaging ; Male ; Mobility ; Nerve Fibers, Myelinated - pathology ; Neurology ; Prospective Studies ; Splenium of corpus callosum ; Vertebrates: nervous system and sense organs ; Walking - physiology ; White matter ; White matter hyperintensity</subject><ispartof>Neurobiology of aging, 2011-04, Vol.32 (4), p.646-654</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2009 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-2032d043e907ccfe81b4380abbcadd228d329471a0858d8a4a8e18a929947413</citedby><cites>FETCH-LOGICAL-c611t-2032d043e907ccfe81b4380abbcadd228d329471a0858d8a4a8e18a929947413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2009.04.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24082346$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19428145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moscufo, Nicola</creatorcontrib><creatorcontrib>Guttmann, Charles R.G</creatorcontrib><creatorcontrib>Meier, Dominik</creatorcontrib><creatorcontrib>Csapo, Istvan</creatorcontrib><creatorcontrib>Hildenbrand, Peter G</creatorcontrib><creatorcontrib>Healy, Brian C</creatorcontrib><creatorcontrib>Schmidt, Julia A</creatorcontrib><creatorcontrib>Wolfson, Leslie</creatorcontrib><title>Brain regional lesion burden and impaired mobility in the elderly</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects ≥75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the splenium of corpus callosum (SCC) demonstrated the highest correlation particularly with walking speed ( r = 0.4, p < 10−4 ), and in logistic regression it was the best regional predictor of low mobility performance. We also found that independent of mobility, corona radiata has the largest lesion burden with anterior (ACR) and posterior (PCR) aspects being the most frequently affected. The results suggest that compromised inter-hemispheric integration of visuospatial information through the SCC plays an important role in mobility impairment in the elderly. The relatively high lesion susceptibility of ACR and PCR in all subjects may obscure the importance of these lesions in mobility impairment.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Corona radiata</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gait - physiology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Internal Medicine</subject><subject>Logistic Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mobility</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>Neurology</subject><subject>Prospective Studies</subject><subject>Splenium of corpus callosum</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Walking - physiology</subject><subject>White matter</subject><subject>White matter hyperintensity</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNklFvFCEUhYnR2LX6F8w8aHya8cIwAySmSW2smjTxwb4TBu5uWRlmhZkm--9ls5tqfeoTBL577oVzCHlHoaFA-4_bJuKSpsFPwWx83DQMQDXAG6DwjKxo18maciWekxVQJWreSTgjr3LeAoDgon9JzqjiTFLercjl52R8rBJu_BRNqALmsqmGJTmMlYmu8uPO-ISuGkvP4Od9Vfj5DisMDlPYvyYv1iZkfHNaz8nt9Zfbq2_1zY-v368ub2rbUzrXDFrmgLeoQFi7RkkH3koww2CNc4xJ1zLFBTUgO-mk4UYilUYxVU45bc_JxVF2twwjOotxTiboXfKjSXs9Ga8f30R_pzfTvS6qTHWiCHw4CaTp94J51qPPFkMwEacla9kzITugTyA7Vf63FbKQn46kTVPOCdcP81DQB7f0Vj92Sx_c0sB1cauUv_33TX-LT_YU4P0JMNmasE4mWp8fOMZBspb3hbs-clgMuPeYdLYeo0VXnLOzdpN_6kQX_wnZ4KMvvX_hHvN2WlJJSdZUZ6ZB_zwk7BAwUACUg2j_AByl0PI</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Moscufo, Nicola</creator><creator>Guttmann, Charles R.G</creator><creator>Meier, Dominik</creator><creator>Csapo, Istvan</creator><creator>Hildenbrand, Peter G</creator><creator>Healy, Brian C</creator><creator>Schmidt, Julia A</creator><creator>Wolfson, Leslie</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20110401</creationdate><title>Brain regional lesion burden and impaired mobility in the elderly</title><author>Moscufo, Nicola ; Guttmann, Charles R.G ; Meier, Dominik ; Csapo, Istvan ; Hildenbrand, Peter G ; Healy, Brian C ; Schmidt, Julia A ; Wolfson, Leslie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-2032d043e907ccfe81b4380abbcadd228d329471a0858d8a4a8e18a929947413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Corona radiata</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gait - physiology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Internal Medicine</topic><topic>Logistic Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mobility</topic><topic>Nerve Fibers, Myelinated - pathology</topic><topic>Neurology</topic><topic>Prospective Studies</topic><topic>Splenium of corpus callosum</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Walking - physiology</topic><topic>White matter</topic><topic>White matter hyperintensity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moscufo, Nicola</creatorcontrib><creatorcontrib>Guttmann, Charles R.G</creatorcontrib><creatorcontrib>Meier, Dominik</creatorcontrib><creatorcontrib>Csapo, Istvan</creatorcontrib><creatorcontrib>Hildenbrand, Peter G</creatorcontrib><creatorcontrib>Healy, Brian C</creatorcontrib><creatorcontrib>Schmidt, Julia A</creatorcontrib><creatorcontrib>Wolfson, Leslie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moscufo, Nicola</au><au>Guttmann, Charles R.G</au><au>Meier, Dominik</au><au>Csapo, Istvan</au><au>Hildenbrand, Peter G</au><au>Healy, Brian C</au><au>Schmidt, Julia A</au><au>Wolfson, Leslie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain regional lesion burden and impaired mobility in the elderly</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>32</volume><issue>4</issue><spage>646</spage><epage>654</epage><pages>646-654</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Abstract This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects ≥75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the splenium of corpus callosum (SCC) demonstrated the highest correlation particularly with walking speed ( r = 0.4, p < 10−4 ), and in logistic regression it was the best regional predictor of low mobility performance. We also found that independent of mobility, corona radiata has the largest lesion burden with anterior (ACR) and posterior (PCR) aspects being the most frequently affected. The results suggest that compromised inter-hemispheric integration of visuospatial information through the SCC plays an important role in mobility impairment in the elderly. 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| subjects | Aged Aged, 80 and over Aging Aging - pathology Aging - physiology Biological and medical sciences Brain Brain - pathology Corona radiata Development. Senescence. Regeneration. Transplantation Female Fundamental and applied biological sciences. Psychology Gait - physiology Humans Image Processing, Computer-Assisted Internal Medicine Logistic Models Magnetic Resonance Imaging Male Mobility Nerve Fibers, Myelinated - pathology Neurology Prospective Studies Splenium of corpus callosum Vertebrates: nervous system and sense organs Walking - physiology White matter White matter hyperintensity |
| title | Brain regional lesion burden and impaired mobility in the elderly |
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