A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including those regulated by MYC, MYCN, FLT3-ITD, BCR-ABL, HOXA9, and EWS fusions. We demonstrate that SMI-4a, a novel benzylidene-thiazolidine-2, 4-di...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2010-01, Vol.115 (4), p.824-833
Hauptverfasser:	Lin, Ying-Wei, Beharry, Zanna M., Hill, Elizabeth G., Song, Jin H., Wang, Wenxue, Xia, Zuping, Zhang, Zhenhua, Aplan, Peter D., Aster, Jon C., Smith, Charles D., Kraft, Andrew S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Benzylidene Compounds - pharmacology Biological and medical sciences Cell Division - drug effects Cell Line, Tumor Extracellular Signal-Regulated MAP Kinases - metabolism G1 Phase - drug effects Hematologic and hematopoietic diseases Humans Intracellular Signaling Peptides and Proteins - metabolism Jurkat Cells Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoid Neoplasia MAP Kinase Signaling System - drug effects Medical sciences Mice Mice, Knockout Mice, Transgenic Phosphorylation - drug effects Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors Proto-Oncogene Proteins c-pim-1 - genetics Proto-Oncogene Proteins c-pim-1 - metabolism Thiazolidinediones - pharmacology TOR Serine-Threonine Kinases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!