Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2

Production of leukotriene B4 (LTB4) by human neutrophils (PMN) in response to different stimuli is increased after pretreatment with lipopolysaccharides (LPS). We have analyzed the steps in arachidonic acid (AA) metabolism affected by LPS by examining release of AA and its metabolites from [3H]AA pr...

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Veröffentlicht in:	The Journal of clinical investigation 1994-04, Vol.93 (4), p.1583-1591
Hauptverfasser:	DOERFLER, M. E, WEISS, J, CLARK, J. D, ELSBACH, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins Alkaloids - pharmacology Animals Antigens, CD - physiology Antigens, Differentiation, Myelomonocytic - physiology Arachidonic Acid - metabolism Biological and medical sciences Carrier Proteins - physiology CHO Cells Cricetinae Cricetulus Cytosol - enzymology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Leukotriene B4 - biosynthesis Lipopolysaccharide Receptors Lipopolysaccharides - pharmacology Membrane Glycoproteins Myeloid cells: ontogeny, maturation, markers, receptors Neutrophils - drug effects Neutrophils - metabolism Phospholipases A - metabolism Phospholipases A2 Phospholipids - metabolism Phosphorylation Polynuclears Staurosporine Tetradecanoylphorbol Acetate - pharmacology Zymosan - metabolism
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