Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides

The cell cycle regulatory enzyme, cdk (cyclin-dependent kinase) 2 kinase, is activated in the rat carotid artery after balloon angioplasty injury, and may mediate smooth muscle proliferation. To test the hypothesis that inhibition of the expression of this key enzyme can inhibit intimal hyperplasia,...

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Veröffentlicht in:	The Journal of clinical investigation 1994-04, Vol.93 (4), p.1458-1464
Hauptverfasser:	MORISHITA, R, GIBBONS, G. H, ELLISON, K. E, NAKAJIMA, M, VON DER LEYEN, H, LUNAN ZHANG, KANEDA, Y, OGIHARA, T, DZAU, V. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angioplasty, Balloon - adverse effects Animals Base Sequence Biological and medical sciences CDC2-CDC28 Kinases Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinases Diseases of the cardiovascular system Fluorescein-5-isothiocyanate Hyperplasia Male Medical sciences Molecular Sequence Data Muscle, Smooth, Vascular - pathology Oligonucleotides, Antisense - pharmacology Polymerase Chain Reaction Protein Kinases - genetics Protein Kinases - physiology Protein-Serine-Threonine Kinases Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Sprague-Dawley RNA, Messenger - analysis Thionucleotides - pharmacology
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