Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice
Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been used to study the effect of different cholesterol-containing diets on the remnant lipoprotein levels and composition and on the possible concurrent development of atherosclerotic plaques. On high fat/cholesterol (HFC) diet, the high...
Gespeichert in:
Veröffentlicht in: | The Journal of clinical investigation 1994-04, Vol.93 (4), p.1403-1410 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1410 |
---|---|
container_issue | 4 |
container_start_page | 1403 |
container_title | The Journal of clinical investigation |
container_volume | 93 |
creator | VAN VLIJMEN, B. J. M VAN DEN MAAGDENBERG, A. M. J. M GIJBELS, M. J. J VAN DER BOOM, H HOGENESCH, H FRANTS, R. R HOFKER, M. H HAVEKES, L. M |
description | Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been used to study the effect of different cholesterol-containing diets on the remnant lipoprotein levels and composition and on the possible concurrent development of atherosclerotic plaques. On high fat/cholesterol (HFC) diet, the high expressing lines 2 and 181 developed severe hypercholesterolemia (up to 40 and 60 mmol/liter, respectively), whereas triglyceride levels remained almost normal when compared with regular mouse diet. The addition of cholate increased the hypercholesterolemic effect of this diet. In lines 2 and 181, serum levels of apo E3-Leiden also increased dramatically upon cholesterol feeding (up to 107 and 300 mg/dl, respectively). In these high expressing APOE*3-Leiden transgenic mice, the increase in both serum cholesterol and apo E3-Leiden occurred mainly in the VLDL/LDL-sized fractions, whereas a considerable increase in large, apo E-rich HDL particles also occurred. In contrast to the high expressing lines, the low expressing line 195 reacted only mildly upon HFC diet. On HFC diets, the high expresser APOE*3-Leiden mice developed atherosclerotic lesions in the aortic arch, the descending aorta, and the carotid arteries, varying from fatty streaks containing foam cells to severe atherosclerotic plaques containing cholesterol crystals, fibrosis, and necrotic calcified tissue. Quantitative evaluation revealed that the atherogenesis is positively correlated with the serum level of cholesterol-rich VLDL/LDL particles. In conclusion, with APOE*3-Leiden transgenic mice, factors can be studied that influence the metabolism of remnant VLDL and the development of atherosclerosis. |
doi_str_mv | 10.1172/JCI117117 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_294153</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76451799</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-35cf1b5065f4e0bc48e01eec8907e9b7bf591987a13fba224febc8af641ffc9f3</originalsourceid><addsrcrecordid>eNpVkU1LxDAQhoMoun4c_AFCDyJ4qGaaZJscPMj6zYIXPYc0nbiRNq1NV_Dfm2WXRWGYObzPfPAOIadArwDK4vpl9pxqih0yASFkLgsmd8mE0gJyVTJ5QA5j_KQUOBd8n-xLmLIpFxNi7jyOuQ_10mKdLX56HBrfd_3QjegDtt5kJtSZGRc4dNE2q-xj5kNm-u4Pmd2zfI6-xpCNgwnxA4O3WestHpM9Z5qIJ5t6RN4f7t9mT_n89fF5djvPLVNyzJmwDipBp8JxpJXlEikgWqloiaoqKycUKFkaYK4yRcEdVlYaN-XgnFWOHZGb9dx-WbVYWwzpkEb3g2_N8KM74_V_JfiF_ui-daE4CJb6Lzb9Q_e1xDjq1keLTWMCdsuoy-QXlEol8HIN2uRFHNBtdwDVq3fo7TsSe_b3qC258T_p5xvdRGsal6yzPm4xTkEoBewX33uVlg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76451799</pqid></control><display><type>article</type><title>Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>VAN VLIJMEN, B. J. M ; VAN DEN MAAGDENBERG, A. M. J. M ; GIJBELS, M. J. J ; VAN DER BOOM, H ; HOGENESCH, H ; FRANTS, R. R ; HOFKER, M. H ; HAVEKES, L. M</creator><creatorcontrib>VAN VLIJMEN, B. J. M ; VAN DEN MAAGDENBERG, A. M. J. M ; GIJBELS, M. J. J ; VAN DER BOOM, H ; HOGENESCH, H ; FRANTS, R. R ; HOFKER, M. H ; HAVEKES, L. M</creatorcontrib><description>Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been used to study the effect of different cholesterol-containing diets on the remnant lipoprotein levels and composition and on the possible concurrent development of atherosclerotic plaques. On high fat/cholesterol (HFC) diet, the high expressing lines 2 and 181 developed severe hypercholesterolemia (up to 40 and 60 mmol/liter, respectively), whereas triglyceride levels remained almost normal when compared with regular mouse diet. The addition of cholate increased the hypercholesterolemic effect of this diet. In lines 2 and 181, serum levels of apo E3-Leiden also increased dramatically upon cholesterol feeding (up to 107 and 300 mg/dl, respectively). In these high expressing APOE*3-Leiden transgenic mice, the increase in both serum cholesterol and apo E3-Leiden occurred mainly in the VLDL/LDL-sized fractions, whereas a considerable increase in large, apo E-rich HDL particles also occurred. In contrast to the high expressing lines, the low expressing line 195 reacted only mildly upon HFC diet. On HFC diets, the high expresser APOE*3-Leiden mice developed atherosclerotic lesions in the aortic arch, the descending aorta, and the carotid arteries, varying from fatty streaks containing foam cells to severe atherosclerotic plaques containing cholesterol crystals, fibrosis, and necrotic calcified tissue. Quantitative evaluation revealed that the atherogenesis is positively correlated with the serum level of cholesterol-rich VLDL/LDL particles. In conclusion, with APOE*3-Leiden transgenic mice, factors can be studied that influence the metabolism of remnant VLDL and the development of atherosclerosis.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/JCI117117</identifier><identifier>PMID: 8163645</identifier><identifier>CODEN: JCINAO</identifier><language>eng</language><publisher>Ann Arbor, MI: American Society for Clinical Investigation</publisher><subject>Animals ; Apolipoprotein E3 ; Apolipoproteins E - analysis ; Apolipoproteins E - genetics ; Arteriosclerosis - etiology ; Arteriosclerosis - pathology ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cholesterol, Dietary - administration & dosage ; Female ; Hyperlipoproteinemias - etiology ; Lipids - blood ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Transgenic ; Sex Factors</subject><ispartof>The Journal of clinical investigation, 1994-04, Vol.93 (4), p.1403-1410</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-35cf1b5065f4e0bc48e01eec8907e9b7bf591987a13fba224febc8af641ffc9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC294153/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC294153/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4015991$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8163645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN VLIJMEN, B. J. M</creatorcontrib><creatorcontrib>VAN DEN MAAGDENBERG, A. M. J. M</creatorcontrib><creatorcontrib>GIJBELS, M. J. J</creatorcontrib><creatorcontrib>VAN DER BOOM, H</creatorcontrib><creatorcontrib>HOGENESCH, H</creatorcontrib><creatorcontrib>FRANTS, R. R</creatorcontrib><creatorcontrib>HOFKER, M. H</creatorcontrib><creatorcontrib>HAVEKES, L. M</creatorcontrib><title>Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been used to study the effect of different cholesterol-containing diets on the remnant lipoprotein levels and composition and on the possible concurrent development of atherosclerotic plaques. On high fat/cholesterol (HFC) diet, the high expressing lines 2 and 181 developed severe hypercholesterolemia (up to 40 and 60 mmol/liter, respectively), whereas triglyceride levels remained almost normal when compared with regular mouse diet. The addition of cholate increased the hypercholesterolemic effect of this diet. In lines 2 and 181, serum levels of apo E3-Leiden also increased dramatically upon cholesterol feeding (up to 107 and 300 mg/dl, respectively). In these high expressing APOE*3-Leiden transgenic mice, the increase in both serum cholesterol and apo E3-Leiden occurred mainly in the VLDL/LDL-sized fractions, whereas a considerable increase in large, apo E-rich HDL particles also occurred. In contrast to the high expressing lines, the low expressing line 195 reacted only mildly upon HFC diet. On HFC diets, the high expresser APOE*3-Leiden mice developed atherosclerotic lesions in the aortic arch, the descending aorta, and the carotid arteries, varying from fatty streaks containing foam cells to severe atherosclerotic plaques containing cholesterol crystals, fibrosis, and necrotic calcified tissue. Quantitative evaluation revealed that the atherogenesis is positively correlated with the serum level of cholesterol-rich VLDL/LDL particles. In conclusion, with APOE*3-Leiden transgenic mice, factors can be studied that influence the metabolism of remnant VLDL and the development of atherosclerosis.</description><subject>Animals</subject><subject>Apolipoprotein E3</subject><subject>Apolipoproteins E - analysis</subject><subject>Apolipoproteins E - genetics</subject><subject>Arteriosclerosis - etiology</subject><subject>Arteriosclerosis - pathology</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cholesterol, Dietary - administration & dosage</subject><subject>Female</subject><subject>Hyperlipoproteinemias - etiology</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Mice, Transgenic</subject><subject>Sex Factors</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1LxDAQhoMoun4c_AFCDyJ4qGaaZJscPMj6zYIXPYc0nbiRNq1NV_Dfm2WXRWGYObzPfPAOIadArwDK4vpl9pxqih0yASFkLgsmd8mE0gJyVTJ5QA5j_KQUOBd8n-xLmLIpFxNi7jyOuQ_10mKdLX56HBrfd_3QjegDtt5kJtSZGRc4dNE2q-xj5kNm-u4Pmd2zfI6-xpCNgwnxA4O3WestHpM9Z5qIJ5t6RN4f7t9mT_n89fF5djvPLVNyzJmwDipBp8JxpJXlEikgWqloiaoqKycUKFkaYK4yRcEdVlYaN-XgnFWOHZGb9dx-WbVYWwzpkEb3g2_N8KM74_V_JfiF_ui-daE4CJb6Lzb9Q_e1xDjq1keLTWMCdsuoy-QXlEol8HIN2uRFHNBtdwDVq3fo7TsSe_b3qC258T_p5xvdRGsal6yzPm4xTkEoBewX33uVlg</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>VAN VLIJMEN, B. J. M</creator><creator>VAN DEN MAAGDENBERG, A. M. J. M</creator><creator>GIJBELS, M. J. J</creator><creator>VAN DER BOOM, H</creator><creator>HOGENESCH, H</creator><creator>FRANTS, R. R</creator><creator>HOFKER, M. H</creator><creator>HAVEKES, L. M</creator><general>American Society for Clinical Investigation</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940401</creationdate><title>Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice</title><author>VAN VLIJMEN, B. J. M ; VAN DEN MAAGDENBERG, A. M. J. M ; GIJBELS, M. J. J ; VAN DER BOOM, H ; HOGENESCH, H ; FRANTS, R. R ; HOFKER, M. H ; HAVEKES, L. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-35cf1b5065f4e0bc48e01eec8907e9b7bf591987a13fba224febc8af641ffc9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Apolipoprotein E3</topic><topic>Apolipoproteins E - analysis</topic><topic>Apolipoproteins E - genetics</topic><topic>Arteriosclerosis - etiology</topic><topic>Arteriosclerosis - pathology</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cholesterol, Dietary - administration & dosage</topic><topic>Female</topic><topic>Hyperlipoproteinemias - etiology</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Mice, Transgenic</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN VLIJMEN, B. J. M</creatorcontrib><creatorcontrib>VAN DEN MAAGDENBERG, A. M. J. M</creatorcontrib><creatorcontrib>GIJBELS, M. J. J</creatorcontrib><creatorcontrib>VAN DER BOOM, H</creatorcontrib><creatorcontrib>HOGENESCH, H</creatorcontrib><creatorcontrib>FRANTS, R. R</creatorcontrib><creatorcontrib>HOFKER, M. H</creatorcontrib><creatorcontrib>HAVEKES, L. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN VLIJMEN, B. J. M</au><au>VAN DEN MAAGDENBERG, A. M. J. M</au><au>GIJBELS, M. J. J</au><au>VAN DER BOOM, H</au><au>HOGENESCH, H</au><au>FRANTS, R. R</au><au>HOFKER, M. H</au><au>HAVEKES, L. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>93</volume><issue>4</issue><spage>1403</spage><epage>1410</epage><pages>1403-1410</pages><issn>0021-9738</issn><eissn>1558-8238</eissn><coden>JCINAO</coden><abstract>Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been used to study the effect of different cholesterol-containing diets on the remnant lipoprotein levels and composition and on the possible concurrent development of atherosclerotic plaques. On high fat/cholesterol (HFC) diet, the high expressing lines 2 and 181 developed severe hypercholesterolemia (up to 40 and 60 mmol/liter, respectively), whereas triglyceride levels remained almost normal when compared with regular mouse diet. The addition of cholate increased the hypercholesterolemic effect of this diet. In lines 2 and 181, serum levels of apo E3-Leiden also increased dramatically upon cholesterol feeding (up to 107 and 300 mg/dl, respectively). In these high expressing APOE*3-Leiden transgenic mice, the increase in both serum cholesterol and apo E3-Leiden occurred mainly in the VLDL/LDL-sized fractions, whereas a considerable increase in large, apo E-rich HDL particles also occurred. In contrast to the high expressing lines, the low expressing line 195 reacted only mildly upon HFC diet. On HFC diets, the high expresser APOE*3-Leiden mice developed atherosclerotic lesions in the aortic arch, the descending aorta, and the carotid arteries, varying from fatty streaks containing foam cells to severe atherosclerotic plaques containing cholesterol crystals, fibrosis, and necrotic calcified tissue. Quantitative evaluation revealed that the atherogenesis is positively correlated with the serum level of cholesterol-rich VLDL/LDL particles. In conclusion, with APOE*3-Leiden transgenic mice, factors can be studied that influence the metabolism of remnant VLDL and the development of atherosclerosis.</abstract><cop>Ann Arbor, MI</cop><pub>American Society for Clinical Investigation</pub><pmid>8163645</pmid><doi>10.1172/JCI117117</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0021-9738 |
ispartof | The Journal of clinical investigation, 1994-04, Vol.93 (4), p.1403-1410 |
issn | 0021-9738 1558-8238 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_294153 |
source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
subjects | Animals Apolipoprotein E3 Apolipoproteins E - analysis Apolipoproteins E - genetics Arteriosclerosis - etiology Arteriosclerosis - pathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholesterol, Dietary - administration & dosage Female Hyperlipoproteinemias - etiology Lipids - blood Male Medical sciences Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Sex Factors |
title | Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T13%3A43%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diet-induced%20hyperlipoproteinemia%20and%20atherosclerosis%20in%20apolipoprotein%20E3-Leiden%20transgenic%20mice&rft.jtitle=The%20Journal%20of%20clinical%20investigation&rft.au=VAN%20VLIJMEN,%20B.%20J.%20M&rft.date=1994-04-01&rft.volume=93&rft.issue=4&rft.spage=1403&rft.epage=1410&rft.pages=1403-1410&rft.issn=0021-9738&rft.eissn=1558-8238&rft.coden=JCINAO&rft_id=info:doi/10.1172/JCI117117&rft_dat=%3Cproquest_pubme%3E76451799%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76451799&rft_id=info:pmid/8163645&rfr_iscdi=true |