Altered ferritin subunit composition: change in iron metabolism in lens epithelial cells and downstream effects on glutathione levels and VEGF secretion

The iron storage protein ferritin is necessary for the safe storage of iron and for protection against the production of iron-catalyzed oxidative damage. Ferritin is composed of 24 subunits of two types: heavy (H) and light (L). The ratio of these subunits is tissue specific, and alteration of this...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2010-09, Vol.51 (9), p.4437-4446
Hauptverfasser:	Harned, Jill, Ferrell, Jenny, Lall, Marilyn M, Fleisher, Lloyd N, Nagar, Steven, Goralska, Malgorzata, McGahan, M Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoferritins - genetics Apoferritins - metabolism Cell Nucleus - metabolism Cells, Cultured Culture Media, Conditioned - pharmacology Cystine - pharmacokinetics Dogs Epithelial Cells - cytology Epithelial Cells - metabolism Glutathione - metabolism Homeostasis - physiology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Iron - metabolism Lens, Crystalline - cytology Lens, Crystalline - metabolism Oxidative Stress - physiology Protein Subunits - genetics Protein Subunits - metabolism RNA, Small Interfering Transfection Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - secretion
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