The Promise of MicroRNA Replacement Therapy
MicroRNAs (miRNA), a class of natural RNA-interfering agents, have recently been identified as attractive targets for therapeutic intervention. The rationale for developing miRNA therapeutics is based on the premise that aberrantly expressed miRNAs play key roles in the development of human disease,...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2010-09, Vol.70 (18), p.7027-7030 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | BADER, Andreas G BROWN, David WINKLES, Matthew |
| description | MicroRNAs (miRNA), a class of natural RNA-interfering agents, have recently been identified as attractive targets for therapeutic intervention. The rationale for developing miRNA therapeutics is based on the premise that aberrantly expressed miRNAs play key roles in the development of human disease, and that correcting these miRNA deficiencies by either antagonizing or restoring miRNA function may provide a therapeutic benefit. Although miRNA antagonists are conceptually similar to other inhibitory therapies, restoring the function of a miRNA by miRNA replacement is a less well characterized approach. Here, we discuss the specific properties of miRNA replacement and review recent examples that explored the therapeutic delivery of miRNA mimics in animal models of cancer. |
| doi_str_mv | 10.1158/0008-5472.can-10-2010 |
| format | Article |
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Here, we discuss the specific properties of miRNA replacement and review recent examples that explored the therapeutic delivery of miRNA mimics in animal models of cancer.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Genetic Therapy - methods</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>MicroRNAs - administration & dosage</subject><subject>MicroRNAs - antagonists & inhibitors</subject><subject>MicroRNAs - genetics</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - therapy</subject><subject>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 2010-09, Vol.70 (18), p.7027-7030 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antineoplastic agents Biological and medical sciences Genetic Therapy - methods Humans Medical sciences MicroRNAs - administration & dosage MicroRNAs - antagonists & inhibitors MicroRNAs - genetics Neoplasms - genetics Neoplasms - therapy Pharmacology. Drug treatments Tumors |
| title | The Promise of MicroRNA Replacement Therapy |
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