Elevated blood markers 1 year before manifestation of malignant glioma
We detected distinct plasma concentration profiles of S100B, neuropeptide Y, and secretagogin in 3 of 191 patients enrolled in a previous study investigating brain-tissue-related markers in the blood of patients with atrial fibrillation. Intriguingly, 2 of these 3 patients, both of whom were without...
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| Veröffentlicht in: | Neuro-oncology (Charlottesville, Va.) Va.), 2010-09, Vol.12 (9), p.1004-1008 |
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| container_title | Neuro-oncology (Charlottesville, Va.) |
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| creator | Gartner, Wolfgang Ilhan, Aysegül Neziri, Dashurie Base, Wolfgang Weissel, Michael Wöhrer, Adelheid Heinzl, Harald Waldhör, Thomas Wagner, Ludwig Preusser, Matthias |
| description | We detected distinct plasma concentration profiles of S100B, neuropeptide Y, and secretagogin in 3 of 191 patients enrolled in a previous study investigating brain-tissue-related markers in the blood of patients with atrial fibrillation. Intriguingly, 2 of these 3 patients, both of whom were without neurological symptoms at the time of blood sampling, were diagnosed with malignant glioma (MG) approximately 1 year later. To our knowledge, this is the first report indicating that distinct blood biomarker profiles may be detected long before clinical manifestation of MG. |
| doi_str_mv | 10.1093/neuonc/noq034 |
| format | Article |
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Intriguingly, 2 of these 3 patients, both of whom were without neurological symptoms at the time of blood sampling, were diagnosed with malignant glioma (MG) approximately 1 year later. To our knowledge, this is the first report indicating that distinct blood biomarker profiles may be detected long before clinical manifestation of MG.</description><identifier>ISSN: 1522-8517</identifier><identifier>EISSN: 1523-5866</identifier><identifier>DOI: 10.1093/neuonc/noq034</identifier><identifier>PMID: 20378688</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Atrial Fibrillation - blood ; Biomarkers, Tumor - blood ; Brain Neoplasms - blood ; Calcium-Binding Proteins - blood ; Female ; Glioma - blood ; Humans ; Male ; Middle Aged ; Nerve Growth Factors - blood ; Neuropeptide Y - blood ; Reviews ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins - blood ; Secretagogins ; Young Adult</subject><ispartof>Neuro-oncology (Charlottesville, Va.), 2010-09, Vol.12 (9), p.1004-1008</ispartof><rights>The Author(s) 2010. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-7634287dbf694b35f70512e2e8b3faaa4347390c3f00d78cae9a2375e390fa663</citedby><cites>FETCH-LOGICAL-c419t-7634287dbf694b35f70512e2e8b3faaa4347390c3f00d78cae9a2375e390fa663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940699/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940699/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1584,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20378688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gartner, Wolfgang</creatorcontrib><creatorcontrib>Ilhan, Aysegül</creatorcontrib><creatorcontrib>Neziri, Dashurie</creatorcontrib><creatorcontrib>Base, Wolfgang</creatorcontrib><creatorcontrib>Weissel, Michael</creatorcontrib><creatorcontrib>Wöhrer, Adelheid</creatorcontrib><creatorcontrib>Heinzl, Harald</creatorcontrib><creatorcontrib>Waldhör, Thomas</creatorcontrib><creatorcontrib>Wagner, Ludwig</creatorcontrib><creatorcontrib>Preusser, Matthias</creatorcontrib><title>Elevated blood markers 1 year before manifestation of malignant glioma</title><title>Neuro-oncology (Charlottesville, Va.)</title><addtitle>Neuro Oncol</addtitle><description>We detected distinct plasma concentration profiles of S100B, neuropeptide Y, and secretagogin in 3 of 191 patients enrolled in a previous study investigating brain-tissue-related markers in the blood of patients with atrial fibrillation. Intriguingly, 2 of these 3 patients, both of whom were without neurological symptoms at the time of blood sampling, were diagnosed with malignant glioma (MG) approximately 1 year later. To our knowledge, this is the first report indicating that distinct blood biomarker profiles may be detected long before clinical manifestation of MG.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial Fibrillation - blood</subject><subject>Biomarkers, Tumor - blood</subject><subject>Brain Neoplasms - blood</subject><subject>Calcium-Binding Proteins - blood</subject><subject>Female</subject><subject>Glioma - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Growth Factors - blood</subject><subject>Neuropeptide Y - blood</subject><subject>Reviews</subject><subject>S100 Calcium Binding Protein beta Subunit</subject><subject>S100 Proteins - blood</subject><subject>Secretagogins</subject><subject>Young Adult</subject><issn>1522-8517</issn><issn>1523-5866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDlPxDAQhS0E4lgoaVE6aML6io8GCa24JCQaqC0nGS-BrL3YCRL_HkMAQUU1ozef3sw8hA4JPiVYs7mHMfhm7sMLZnwD7ZKKsrJSQmx-9rRUFZE7aC-lJ4wpqQTZRjsUM6mEUrvo8qKHVztAW9R9CG2xsvEZYipI8QY2FjW4ECGrvnOQBjt0wRfBZaHvlt76oVj2XVjZfbTlbJ_g4KvO0MPlxf3iury9u7pZnN-WDSd6KKVgnCrZ1k5oXrPKSVwRChRUzZy1ljMumcYNcxi3UjUWtKVMVpBFZ4VgM3Q2-a7HegVtA36Itjfr2OXD30ywnfk78d2jWYZXQzXHQutscPxlEMPLmF8yqy410PfWQxiTkVxpUXGlMllOZBNDShHczxaCzUf0ZoreTNFn_uj3aT_0d9YZOJmAMK7_8XoHEguQrw</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Gartner, Wolfgang</creator><creator>Ilhan, Aysegül</creator><creator>Neziri, Dashurie</creator><creator>Base, Wolfgang</creator><creator>Weissel, Michael</creator><creator>Wöhrer, Adelheid</creator><creator>Heinzl, Harald</creator><creator>Waldhör, Thomas</creator><creator>Wagner, Ludwig</creator><creator>Preusser, Matthias</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Elevated blood markers 1 year before manifestation of malignant glioma</title><author>Gartner, Wolfgang ; Ilhan, Aysegül ; Neziri, Dashurie ; Base, Wolfgang ; Weissel, Michael ; Wöhrer, Adelheid ; Heinzl, Harald ; Waldhör, Thomas ; Wagner, Ludwig ; Preusser, Matthias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-7634287dbf694b35f70512e2e8b3faaa4347390c3f00d78cae9a2375e390fa663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial Fibrillation - blood</topic><topic>Biomarkers, Tumor - blood</topic><topic>Brain Neoplasms - blood</topic><topic>Calcium-Binding Proteins - blood</topic><topic>Female</topic><topic>Glioma - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Growth Factors - blood</topic><topic>Neuropeptide Y - blood</topic><topic>Reviews</topic><topic>S100 Calcium Binding Protein beta Subunit</topic><topic>S100 Proteins - blood</topic><topic>Secretagogins</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gartner, Wolfgang</creatorcontrib><creatorcontrib>Ilhan, Aysegül</creatorcontrib><creatorcontrib>Neziri, Dashurie</creatorcontrib><creatorcontrib>Base, Wolfgang</creatorcontrib><creatorcontrib>Weissel, Michael</creatorcontrib><creatorcontrib>Wöhrer, Adelheid</creatorcontrib><creatorcontrib>Heinzl, Harald</creatorcontrib><creatorcontrib>Waldhör, Thomas</creatorcontrib><creatorcontrib>Wagner, Ludwig</creatorcontrib><creatorcontrib>Preusser, Matthias</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gartner, Wolfgang</au><au>Ilhan, Aysegül</au><au>Neziri, Dashurie</au><au>Base, Wolfgang</au><au>Weissel, Michael</au><au>Wöhrer, Adelheid</au><au>Heinzl, Harald</au><au>Waldhör, Thomas</au><au>Wagner, Ludwig</au><au>Preusser, Matthias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated blood markers 1 year before manifestation of malignant glioma</atitle><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle><addtitle>Neuro Oncol</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>12</volume><issue>9</issue><spage>1004</spage><epage>1008</epage><pages>1004-1008</pages><issn>1522-8517</issn><eissn>1523-5866</eissn><abstract>We detected distinct plasma concentration profiles of S100B, neuropeptide Y, and secretagogin in 3 of 191 patients enrolled in a previous study investigating brain-tissue-related markers in the blood of patients with atrial fibrillation. 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| ispartof | Neuro-oncology (Charlottesville, Va.), 2010-09, Vol.12 (9), p.1004-1008 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adolescent Adult Aged Aged, 80 and over Atrial Fibrillation - blood Biomarkers, Tumor - blood Brain Neoplasms - blood Calcium-Binding Proteins - blood Female Glioma - blood Humans Male Middle Aged Nerve Growth Factors - blood Neuropeptide Y - blood Reviews S100 Calcium Binding Protein beta Subunit S100 Proteins - blood Secretagogins Young Adult |
| title | Elevated blood markers 1 year before manifestation of malignant glioma |
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