Familial testicular germ cell tumours

This article defines familial testicular germ cell tumours (FTGCTs) as testicular germ cell tumours (TGCTs) diagnosed in at least two blood relatives, a situation which occurs in 1–2% of all cases of TGCT. Brothers and fathers of TGCT patients have an 8–10- and 4–6-fold increased risk of TGCT, respe...

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Veröffentlicht in:	Baillière's best practice & research. Clinical endocrinology & metabolism 2010-06, Vol.24 (3), p.503-513
Hauptverfasser:	Kratz, Christian P., MD, Mai, Phuong L., MD, Greene, Mark H., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bcl-2 Homologous Antagonist-Killer Protein - genetics Chromosome Deletion Chromosome Mapping Chromosomes, Human, Y Endocrinology & Metabolism familial testicular cancer germ cell tumours genetic susceptibility Genetic Variation - genetics Genome-Wide Association Study Humans Intracellular Signaling Peptides and Proteins - genetics KITLG-KIT signalling Male Neoplasms, Germ Cell and Embryonal - genetics Neoplasms, Germ Cell and Embryonal - pathology Nerve Tissue Proteins - genetics Phosphoric Diester Hydrolases - genetics Testicular Neoplasms - genetics Testicular Neoplasms - pathology
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