Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis

The C apillary M orphogenesis G ene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2), but the normal physiological function is not known. ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultured in vitro . We explor...

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Veröffentlicht in:	Oncogene 2010-02, Vol.29 (6), p.789-801
Hauptverfasser:	Reeves, C V, Dufraine, J, Young, J A T, Kitajewski, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Anthrax Apoptosis Bacterial diseases Biological and medical sciences Breast - blood supply Breast - cytology Breast - metabolism Breast - pathology Breast cancer Capillaries - cytology Capillaries - growth & development Capillaries - pathology Cell Biology Cell Line Cell Movement - genetics Cell physiology Cell Proliferation Cell receptors Cell structures and functions Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Endothelium - growth & development Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Gene Knockdown Techniques Genes Genetic aspects Human bacterial diseases Human Genetics Humans Immunohistochemistry Infectious diseases Internal Medicine Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred C57BL Miscellaneous Molecular and cellular biology Morphogenesis Morphogenesis - genetics Neoplasms - blood supply Neoplasms - genetics Neoplasms - metabolism Neovascularization Neovascularization, Physiologic - genetics Oncology original-article Physiological aspects Receptors, Peptide - deficiency Receptors, Peptide - genetics Receptors, Peptide - metabolism RNA-mediated interference Rodents Tumors Veins & arteries
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