Protective Immunity Against a Lethal Respiratory Yersinia pestis Challenge Induced by V Antigen or the F1 Capsular Antigen Incorporated into Adenovirus Capsid

The aerosol form of the bacterium Yersinia pestis causes pneumonic plague, a rapidly fatal disease that is a biothreat if deliberately released. At present, no plague vaccines are available for use in the United States, but subunit vaccines based on the Y. pestis V antigen and F1 capsular protein sh...

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Veröffentlicht in:	Human gene therapy 2010-07, Vol.21 (7), p.891-901
Hauptverfasser:	BOYER, Julie L, SOFER-PODESTA, Carolina, ANG, John, HACKETT, Neil R, CHIUCHIOLO, Maria J, SENINA, Svetlana, PERLIN, David, CRYSTAL, Ronald G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, Bacterial - immunology Applied cell therapy and gene therapy Bacterial Proteins - immunology Bacterial Vaccines - immunology Biological and medical sciences Biotechnology Blotting, Western Capsid Fundamental and applied biological sciences. Psychology Gene therapy Genetic aspects Genetic Vectors Health. Pharmaceutical industry Immunization Immunotherapy Industrial applications and implications. Economical aspects Medical sciences Plague - immunology Plague - prevention & control Pore Forming Cytotoxic Proteins - immunology Prevention Recombinant Proteins - genetics Recombinant Proteins - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Yersinia pestis Yersinia pestis - genetics Yersinia pestis - immunology
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