PIAS1 regulates CP2c localization and active promoter complex formation in erythroid cell-specific α-globin expression

Data presented here extends our previous observations on α-globin transcriptional regulation by the CP2 and PIAS1 proteins. Using RNAi knockdown, we have now shown that CP2b, CP2c and PIAS1 are each necessary for synergistic activation of endogenous α-globin gene expression in differentiating MEL ce...

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Veröffentlicht in:	Nucleic acids research 2010-09, Vol.38 (16), p.5456-5471
Hauptverfasser:	Chul Kang, Ho, Hyung Chae, Ji, Jeon, Jinseon, Kim, Won, Hyun Ha, Dae, Ho Shin, June, Gil Kim, Chan, Geun Kim, Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Globins - genetics Animals Cell Line Cell Line, Tumor Cell Nucleus - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Erythroid Cells - metabolism Humans Mice Molecular Biology Promoter Regions, Genetic Protein Inhibitors of Activated STAT - antagonists & inhibitors Protein Inhibitors of Activated STAT - chemistry Protein Inhibitors of Activated STAT - metabolism Protein Interaction Domains and Motifs RNA Interference Transcription Factors - antagonists & inhibitors Transcription Factors - chemistry Transcription Factors - metabolism Transcriptional Activation
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