Circulating DNA microsatellites: Molecular determinants of response to biochemotherapy in patients with metastatic melanoma

Although biochemotherapy appears to be a promising treatment for metastatic melanoma, its impact remains unpredictable. Microsatellite markers for loss of heterozygosity (LOH) appear to have prognostic significance when identified in primary tumors and serum and/or plasma from cancer patients. Howev...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2004-01, Vol.96 (2), p.152-156
Hauptverfasser:	TABACK, Bret, ODAY, Steven J, BOASBERG, Peter D, SHU, Sherry, FOURNIER, Patricia, ELASHOFF, Robert, WANG, He-Jing, HOON, Dave S. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Biomarkers, Tumor - genetics Chemotherapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Deoxyribonucleic acid Dermatology Disease Progression DNA DNA, Neoplasm - analysis Female Humans Loss of Heterozygosity Male Medical research Medical sciences Medical treatment Melanoma - drug therapy Melanoma - genetics Melanoma - secondary Microsatellite Repeats Middle Aged Multivariate Analysis Pharmacology. Drug treatments Predictive Value of Tests Skin cancer Survival Analysis Treatment Outcome Tumors Tumors of the skin and soft tissue. Premalignant lesions
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