Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes

We and others have previously demonstrated that human alveolar macrophages produce more PGE2 in response to lipopolysaccharide (LPS) than do blood monocytes. We hypothesized that this observation was due to a greater increase in prostaglandin H synthase-2 (PGHS-2) enzyme mass in the macrophage compa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 1994, Vol.93 (1), p.391-396
Hauptverfasser:	HEMPEL, S. L, MONICK, M. M, HUNNINGHAKE, G. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Biological and medical sciences Blotting, Northern Bronchoalveolar Lavage Fluid Cells, Cultured Dinoprostone - metabolism Enzyme Induction Fundamental and applied biological sciences. Psychology Humans Isoenzymes - biosynthesis Isoenzymes - blood Isoenzymes - isolation & purification Kinetics Lipopolysaccharides - pharmacology Macrophages, Alveolar - drug effects Macrophages, Alveolar - enzymology Molecular Weight Monocytes - drug effects Monocytes - enzymology Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - blood Prostaglandin-Endoperoxide Synthases - isolation & purification Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics RNA, Messenger - biosynthesis Time Factors Vertebrates: respiratory system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!