A 350 bp region of the proximal promoter of Rds drives cell-type specific gene expression

RDS (retinal degeneration slow) is a photoreceptor-specific tetraspanin protein required for the biogenesis and maintenance of rod and cone outer segments. Mutations in the Rds gene are associated with multiple forms of rod- and cone-dominant retinal degeneration. To gain more insight into the mecha...

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Veröffentlicht in:	Experimental eye research 2010-08, Vol.91 (2), p.186-194
Hauptverfasser:	Cai, Xue, Conley, Shannon M., Cheng, Tong, Al-Ubaidi, Muayyad R., Naash, Muna I.
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Animals Binding Sites Blotting, Western cis-elements Cloning, Molecular Fluorescent Antibody Technique, Indirect Gene Expression Regulation - physiology gene therapy in vitro transfection Intermediate Filament Proteins - genetics Membrane Glycoproteins - genetics Mice Mice, Inbred BALB C Mice, Inbred C57BL Nerve Tissue Proteins - genetics Peripherins Photoreceptor Cells, Vertebrate - metabolism Plasmids promoter activity and specificity Promoter Regions, Genetic - genetics Rds gene Regulatory Sequences, Ribonucleic Acid - genetics Retinal Degeneration - genetics Retinal Neoplasms - genetics Retinoblastoma - genetics Reverse Transcriptase Polymerase Chain Reaction Transcription Factors - genetics Transfection Tumor Cells, Cultured
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