Human airway contraction and formoterol-induced relaxation is determined by Ca2+ oscillations and Ca2+ sensitivity

The etiology of airway hyperresponsiveness associated with asthma requires an understanding of the regulatory mechanisms mediating human airway smooth muscle cell (SMC) contraction. The objective of this study was to determine how human airway SMC contraction (induced by histamine) and relaxation (i...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2010-08, Vol.43 (2), p.179-191
Hauptverfasser:	Ressmeyer, Anna-Rebekka, Bai, Yan, Delmotte, Philippe, Uy, Karl F, Thistlethwaite, Patricia, Fraire, Armando, Sato, Osamu, Ikebe, Mitsuo, Sanderson, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchodilator Agents - pharmacology Calcium - chemistry Calcium - metabolism Calcium Signaling Ethanolamines - pharmacology Formoterol Fumarate Histamine - chemistry Humans Inositol 1,4,5-Trisphosphate - pharmacology Lung - drug effects Lung - pathology Microscopy, Phase-Contrast - methods Muscle Contraction Muscle, Smooth - cytology Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - pathology Oscillometry - methods Ryanodine Receptor Calcium Release Channel - metabolism
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