Type and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions
Abstract Trabecular architecture plays a major role in bone mechanics. Osteoporosis leads to a transition from a plate-like to a more rod-like trabecular morphology, which may contribute to fracture risk beyond that predicted by changes in density. In this study, microstructural finite element analy...
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description | Abstract Trabecular architecture plays a major role in bone mechanics. Osteoporosis leads to a transition from a plate-like to a more rod-like trabecular morphology, which may contribute to fracture risk beyond that predicted by changes in density. In this study, microstructural finite element analysis results were analyzed using individual trabeculae segmentation (ITS) to identify the type and orientation of trabeculae where tissue yielded during compressive overloads in two orthogonal directions. For both apparent loading conditions, most of the yielded tissue was found in longitudinally oriented plates. However, the primary loading mode of yielded trabeculae was axial compression with superposed bending for on-axis loading in contrast to bending for transverse loading. For either loading direction, most plate-like trabeculae yielded in the same loading mode, regardless of their orientation. In contrast, rods oriented parallel to the loading axis yielded in compression, while rods oblique or perpendicular to the loading axis yielded in combined bending and tension. The predominance of tissue yielding in plates during both on-axis and transverse overloading explains why on-axis overloading is detrimental to the off-axis mechanical properties. At the same time, a large fraction of the tissue in rod-like trabeculae parallel to the loading direction yielded in both on-axis and transverse loading. Hence, rods may be more likely to be damaged and potentially resorbed by damage mediated remodeling. |
doi_str_mv | 10.1016/j.jbiomech.2010.05.032 |
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Osteoporosis leads to a transition from a plate-like to a more rod-like trabecular morphology, which may contribute to fracture risk beyond that predicted by changes in density. In this study, microstructural finite element analysis results were analyzed using individual trabeculae segmentation (ITS) to identify the type and orientation of trabeculae where tissue yielded during compressive overloads in two orthogonal directions. For both apparent loading conditions, most of the yielded tissue was found in longitudinally oriented plates. However, the primary loading mode of yielded trabeculae was axial compression with superposed bending for on-axis loading in contrast to bending for transverse loading. For either loading direction, most plate-like trabeculae yielded in the same loading mode, regardless of their orientation. In contrast, rods oriented parallel to the loading axis yielded in compression, while rods oblique or perpendicular to the loading axis yielded in combined bending and tension. The predominance of tissue yielding in plates during both on-axis and transverse overloading explains why on-axis overloading is detrimental to the off-axis mechanical properties. At the same time, a large fraction of the tissue in rod-like trabeculae parallel to the loading direction yielded in both on-axis and transverse loading. Hence, rods may be more likely to be damaged and potentially resorbed by damage mediated remodeling.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2010.05.032</identifier><identifier>PMID: 20554282</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Biomechanical Phenomena ; Biomechanics. Biorheology ; Bone and Bones - anatomy & histology ; Bone and Bones - injuries ; Bones ; Boundary conditions ; Compressive Strength - physiology ; Failed trabeculae ; Finite Element Analysis ; Fundamental and applied biological sciences. Psychology ; Humans ; Mechanical properties ; Osteoporosis ; Physical Medicine and Rehabilitation ; Skeleton and joints ; Studies ; Tissues, organs and organisms biophysics ; Torsion, Mechanical ; Trabecular bone ; Trabecular orientation ; Trabecular type ; Transverse overloading ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of biomechanics, 2010-09, Vol.43 (13), p.2460-2466</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2010 Elsevier Ltd. All rights reserved 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c615t-2106457be4ad18ecb46dd3e16a248431a9453199bc19e3dd269d0af272961e263</citedby><cites>FETCH-LOGICAL-c615t-2106457be4ad18ecb46dd3e16a248431a9453199bc19e3dd269d0af272961e263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1034963937?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23289504$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20554282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Xiutao</creatorcontrib><creatorcontrib>Sherry Liu, X</creatorcontrib><creatorcontrib>Wang, Xiang</creatorcontrib><creatorcontrib>Edward Guo, X</creatorcontrib><creatorcontrib>Niebur, Glen L</creatorcontrib><title>Type and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>Abstract Trabecular architecture plays a major role in bone mechanics. Osteoporosis leads to a transition from a plate-like to a more rod-like trabecular morphology, which may contribute to fracture risk beyond that predicted by changes in density. In this study, microstructural finite element analysis results were analyzed using individual trabeculae segmentation (ITS) to identify the type and orientation of trabeculae where tissue yielded during compressive overloads in two orthogonal directions. For both apparent loading conditions, most of the yielded tissue was found in longitudinally oriented plates. However, the primary loading mode of yielded trabeculae was axial compression with superposed bending for on-axis loading in contrast to bending for transverse loading. For either loading direction, most plate-like trabeculae yielded in the same loading mode, regardless of their orientation. In contrast, rods oriented parallel to the loading axis yielded in compression, while rods oblique or perpendicular to the loading axis yielded in combined bending and tension. The predominance of tissue yielding in plates during both on-axis and transverse overloading explains why on-axis overloading is detrimental to the off-axis mechanical properties. At the same time, a large fraction of the tissue in rod-like trabeculae parallel to the loading direction yielded in both on-axis and transverse loading. Hence, rods may be more likely to be damaged and potentially resorbed by damage mediated remodeling.</description><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics. Biorheology</subject><subject>Bone and Bones - anatomy & histology</subject><subject>Bone and Bones - injuries</subject><subject>Bones</subject><subject>Boundary conditions</subject><subject>Compressive Strength - physiology</subject><subject>Failed trabeculae</subject><subject>Finite Element Analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Mechanical properties</subject><subject>Osteoporosis</subject><subject>Physical Medicine and Rehabilitation</subject><subject>Skeleton and joints</subject><subject>Studies</subject><subject>Tissues, organs and organisms biophysics</subject><subject>Torsion, Mechanical</subject><subject>Trabecular bone</subject><subject>Trabecular orientation</subject><subject>Trabecular type</subject><subject>Transverse overloading</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0021-9290</issn><issn>1873-2380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk1v1DAQhiMEotvCX6giIcQpy_gjH75UVBUFpEocKGfLsSe7Dt54sZOV9t_jsNsu9NKTI_vx65k8k2WXBJYESPWxX_at9RvU6yWFtAnlEhh9kS1IU7OCsgZeZgsASgpBBZxl5zH2AFDzWrzOziiUJacNXWTufr_FXA0m98HiMKrR-iH3Xb636AyafAyqRT05hbmZgh1Wud9hcF6Zv9_dCQh564eU5fx8EMa1X_lBudzYgHqOjW-yV51yEd8e14vs5-3n-5uvxd33L99uru8KXZFyLCiBipd1i1wZ0qBueWUMQ1IpyhvOiBK8ZESIVhOBzBhaCQOqozUVFUFasYvs6pC7ndoNGp36CsrJbbAbFfbSKyv_PxnsWq78TlLBahB1CvhwDAj-94RxlBsbNTqnBvRTlCIpmCvhz5J1yYERVs_kuydk76eQflCUBBgXFUuPJ6o6UDr4GAN2j1UTkLN52csH83I2L6GUyXy6ePlvz4_XHlQn4P0RUFEr1wU1aBtPHKONKGGu89OBw2RoZzHIqNNkaDx4lMbb52u5ehKhnR1sevUX7jGe-paRSpA_5jmdx5SkCU1iKfsDmF7lxQ</recordid><startdate>20100917</startdate><enddate>20100917</enddate><creator>Shi, Xiutao</creator><creator>Sherry Liu, X</creator><creator>Wang, Xiang</creator><creator>Edward Guo, X</creator><creator>Niebur, Glen L</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TB</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100917</creationdate><title>Type and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions</title><author>Shi, Xiutao ; Sherry Liu, X ; Wang, Xiang ; Edward Guo, X ; Niebur, Glen L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c615t-2106457be4ad18ecb46dd3e16a248431a9453199bc19e3dd269d0af272961e263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Biomechanics. Biorheology</topic><topic>Bone and Bones - anatomy & histology</topic><topic>Bone and Bones - injuries</topic><topic>Bones</topic><topic>Boundary conditions</topic><topic>Compressive Strength - physiology</topic><topic>Failed trabeculae</topic><topic>Finite Element Analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Mechanical properties</topic><topic>Osteoporosis</topic><topic>Physical Medicine and Rehabilitation</topic><topic>Skeleton and joints</topic><topic>Studies</topic><topic>Tissues, organs and organisms biophysics</topic><topic>Torsion, Mechanical</topic><topic>Trabecular bone</topic><topic>Trabecular orientation</topic><topic>Trabecular type</topic><topic>Transverse overloading</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Xiutao</creatorcontrib><creatorcontrib>Sherry Liu, X</creatorcontrib><creatorcontrib>Wang, Xiang</creatorcontrib><creatorcontrib>Edward Guo, X</creatorcontrib><creatorcontrib>Niebur, Glen L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomechanics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Xiutao</au><au>Sherry Liu, X</au><au>Wang, Xiang</au><au>Edward Guo, X</au><au>Niebur, Glen L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions</atitle><jtitle>Journal of biomechanics</jtitle><addtitle>J Biomech</addtitle><date>2010-09-17</date><risdate>2010</risdate><volume>43</volume><issue>13</issue><spage>2460</spage><epage>2466</epage><pages>2460-2466</pages><issn>0021-9290</issn><eissn>1873-2380</eissn><abstract>Abstract Trabecular architecture plays a major role in bone mechanics. Osteoporosis leads to a transition from a plate-like to a more rod-like trabecular morphology, which may contribute to fracture risk beyond that predicted by changes in density. In this study, microstructural finite element analysis results were analyzed using individual trabeculae segmentation (ITS) to identify the type and orientation of trabeculae where tissue yielded during compressive overloads in two orthogonal directions. For both apparent loading conditions, most of the yielded tissue was found in longitudinally oriented plates. However, the primary loading mode of yielded trabeculae was axial compression with superposed bending for on-axis loading in contrast to bending for transverse loading. For either loading direction, most plate-like trabeculae yielded in the same loading mode, regardless of their orientation. In contrast, rods oriented parallel to the loading axis yielded in compression, while rods oblique or perpendicular to the loading axis yielded in combined bending and tension. The predominance of tissue yielding in plates during both on-axis and transverse overloading explains why on-axis overloading is detrimental to the off-axis mechanical properties. At the same time, a large fraction of the tissue in rod-like trabeculae parallel to the loading direction yielded in both on-axis and transverse loading. Hence, rods may be more likely to be damaged and potentially resorbed by damage mediated remodeling.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20554282</pmid><doi>10.1016/j.jbiomech.2010.05.032</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Biological and medical sciences Biomechanical Phenomena Biomechanics. Biorheology Bone and Bones - anatomy & histology Bone and Bones - injuries Bones Boundary conditions Compressive Strength - physiology Failed trabeculae Finite Element Analysis Fundamental and applied biological sciences. Psychology Humans Mechanical properties Osteoporosis Physical Medicine and Rehabilitation Skeleton and joints Studies Tissues, organs and organisms biophysics Torsion, Mechanical Trabecular bone Trabecular orientation Trabecular type Transverse overloading Vertebrates: osteoarticular system, musculoskeletal system |
title | Type and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions |
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