Type I interferon signals control Theiler's virus infection site, cellular infiltration and T cell stimulation in the CNS

Abstract Theiler's murine encephalomyelitis virus (TMEV) establishes a persistent infection in the central nervous system (CNS). To examine the role of type I interferon (IFN-I)-mediated signals in TMEV infection, mice lacking a subunit of the type I IFN receptor (IFN-IR KO mice) were utilized....

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Veröffentlicht in:	Journal of neuroimmunology 2010-09, Vol.226 (1), p.27-37
Hauptverfasser:	Jin, Young-Hee, Hou, Wanqiu, Kim, Seung Jae, Fuller, Alyson C, Kang, Bongsu, Goings, Gwen, Miller, Stephen D, Kim, Byung S
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigen-Presenting Cells - immunology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Proliferation - drug effects Central Nervous System - immunology Central Nervous System - virology CNS infiltration Co-stimulatory molecules Cytokines - immunology Cytokines - metabolism Enterovirus Infections - immunology Enterovirus Infections - pathology Enterovirus Infections - virology Female Flow Cytometry - methods Interferon Type I - deficiency Interleukin-17 - metabolism Mice Mice, Knockout Neurology Neutrophil Infiltration - drug effects Neutrophil Infiltration - immunology Receptor, Interferon alpha-beta - deficiency Signal Transduction - immunology Signal Transduction - physiology T cell responses T-Lymphocytes - immunology T-Lymphocytes - virology Theiler's encephalomyelitis virus Theilovirus - pathogenicity TMEV Type I IFNs
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