An endocrine-disrupting chemical, fenvalerate, induces cell cycle progression and collagen type I expression in human uterine leiomyoma and myometrial cells

Fenvalerate (Fen), widely used for its high insecticidal potency and low mammalian toxicity, is classified as an endocrine-disrupting chemical. Recently, Fen has received great attention for its adverse effects on human reproductive health. In this study, we found that Fen (10 μM) had a stimulatory...

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Veröffentlicht in:	Toxicology letters 2010-07, Vol.196 (3), p.133-141
Hauptverfasser:	Gao, Xiaohua, Yu, Linda, Castro, Lysandra, Moore, Alicia B., Hermon, Tonia, Bortner, Carl, Sifre, Maria, Dixon, Darlene
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Biological and medical sciences Bromodeoxyuridine - metabolism Cell Cycle - drug effects Cell growth Cell Proliferation - drug effects Collagen type I Collagen Type I - genetics ECM Endocrine Disruptors - toxicity Female Female genital diseases Fenvalerate Gene Expression Regulation - drug effects Gynecology. Andrology. Obstetrics Humans Leiomyoma Leiomyoma - chemically induced Leiomyoma - metabolism Leiomyoma - pathology Medical sciences Myometrium Myometrium - drug effects Myometrium - metabolism Myometrium - pathology Nitriles - toxicity Pesticides, fertilizers and other agrochemicals toxicology Pyrethrins - toxicity Receptors, Estrogen - physiology RNA, Messenger - analysis Toxicology Tumors Uterine Neoplasms - chemically induced Uterine Neoplasms - metabolism Uterine Neoplasms - pathology
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