Potential therapeutic benefits of strategies directed to mitochondria
The mitochondrion is the most important organelle in determining continued cell survival and cell death. Mitochondrial dysfunction leads to many human maladies, including cardiovascular diseases, neurodegenerative disease, and cancer. These mitochondria-related pathologies range from early infancy t...
Gespeichert in:
Veröffentlicht in: | Antioxidants & redox signaling 2010-08, Vol.13 (3), p.279-347 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 347 |
---|---|
container_issue | 3 |
container_start_page | 279 |
container_title | Antioxidants & redox signaling |
container_volume | 13 |
creator | Camara, Amadou K S Lesnefsky, Edward J Stowe, David F |
description | The mitochondrion is the most important organelle in determining continued cell survival and cell death. Mitochondrial dysfunction leads to many human maladies, including cardiovascular diseases, neurodegenerative disease, and cancer. These mitochondria-related pathologies range from early infancy to senescence. The central premise of this review is that if mitochondrial abnormalities contribute to the pathological state, alleviating the mitochondrial dysfunction would contribute to attenuating the severity or progression of the disease. Therefore, this review will examine the role of mitochondria in the etiology and progression of several diseases and explore potential therapeutic benefits of targeting mitochondria in mitigating the disease processes. Indeed, recent advances in mitochondrial biology have led to selective targeting of drugs designed to modulate and manipulate mitochondrial function and genomics for therapeutic benefit. These approaches to treat mitochondrial dysfunction rationally could lead to selective protection of cells in different tissues and various disease states. However, most of these approaches are in their infancy. |
doi_str_mv | 10.1089/ars.2009.2788 |
format | Article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2936955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A233502866</galeid><sourcerecordid>A233502866</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-d76b051d1bda1e840d3d93eb39c4a99104f8f8e2d37b5509fda3c88e9d86e89d3</originalsourceid><addsrcrecordid>eNptkcFLHTEQxkNpqdb26FUWevC0z8lms0kugoi1BcEe9Byyyex7kd3NM8kT_O_N8qwolBwSJr_vY2Y-Qo4prChIdWZiWjUAatUIKT-RQ8q5qIWg3efl3bAaZNcekG8pPQBAQyl8JQdFAFS07SG5-hsyztmbscobjGaLu-xt1eOMg8-pCkOVcjQZ1x5T5XxEm9FVOVSTz8FuwuyiN9_Jl8GMCX-83kfk_tfV3eXv-ub2-s_lxU1tOVW5dqLrgVNHe2coyhYcc4phz5RtjVIU2kEOEhvHRM85qMEZZqVE5WSHUjl2RM73vttdP6GzpfNoRr2NfjLxWQfj9cef2W_0OjzpRrFOcV4MTl8NYnjcYcp68sniOJoZwy5pwRiDrhVdIX_uybUZUft5CMXQLrS-aBjj0MhuoVb_ocpxOHkbliWW-gdBvRfYGFKKOLw1T0EvgeoSqF4C1UughT95P_Eb_S9B9gK_j5zG</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733306476</pqid></control><display><type>article</type><title>Potential therapeutic benefits of strategies directed to mitochondria</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Camara, Amadou K S ; Lesnefsky, Edward J ; Stowe, David F</creator><creatorcontrib>Camara, Amadou K S ; Lesnefsky, Edward J ; Stowe, David F</creatorcontrib><description>The mitochondrion is the most important organelle in determining continued cell survival and cell death. Mitochondrial dysfunction leads to many human maladies, including cardiovascular diseases, neurodegenerative disease, and cancer. These mitochondria-related pathologies range from early infancy to senescence. The central premise of this review is that if mitochondrial abnormalities contribute to the pathological state, alleviating the mitochondrial dysfunction would contribute to attenuating the severity or progression of the disease. Therefore, this review will examine the role of mitochondria in the etiology and progression of several diseases and explore potential therapeutic benefits of targeting mitochondria in mitigating the disease processes. Indeed, recent advances in mitochondrial biology have led to selective targeting of drugs designed to modulate and manipulate mitochondrial function and genomics for therapeutic benefit. These approaches to treat mitochondrial dysfunction rationally could lead to selective protection of cells in different tissues and various disease states. However, most of these approaches are in their infancy.</description><identifier>ISSN: 1523-0864</identifier><identifier>EISSN: 1557-7716</identifier><identifier>DOI: 10.1089/ars.2009.2788</identifier><identifier>PMID: 20001744</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Aging ; Animals ; Antioxidants - metabolism ; Apoptosis ; Care and treatment ; Complications and side effects ; Comprehensive Invited Reviews ; Disease ; DNA, Mitochondrial - metabolism ; Drug Design ; Electron Transport - physiology ; Genetic aspects ; Humans ; Life Expectancy ; Mitochondria - drug effects ; Mitochondria - physiology ; Mitochondria - ultrastructure ; Mitochondrial diseases ; Mitochondrial Proteins - metabolism ; Oxidative Phosphorylation ; Physiological aspects ; Reactive Nitrogen Species - metabolism ; Reactive Oxygen Species - metabolism</subject><ispartof>Antioxidants & redox signaling, 2010-08, Vol.13 (3), p.279-347</ispartof><rights>COPYRIGHT 2010 Mary Ann Liebert, Inc.</rights><rights>Copyright 2010, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-d76b051d1bda1e840d3d93eb39c4a99104f8f8e2d37b5509fda3c88e9d86e89d3</citedby><cites>FETCH-LOGICAL-c519t-d76b051d1bda1e840d3d93eb39c4a99104f8f8e2d37b5509fda3c88e9d86e89d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20001744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camara, Amadou K S</creatorcontrib><creatorcontrib>Lesnefsky, Edward J</creatorcontrib><creatorcontrib>Stowe, David F</creatorcontrib><title>Potential therapeutic benefits of strategies directed to mitochondria</title><title>Antioxidants & redox signaling</title><addtitle>Antioxid Redox Signal</addtitle><description>The mitochondrion is the most important organelle in determining continued cell survival and cell death. Mitochondrial dysfunction leads to many human maladies, including cardiovascular diseases, neurodegenerative disease, and cancer. These mitochondria-related pathologies range from early infancy to senescence. The central premise of this review is that if mitochondrial abnormalities contribute to the pathological state, alleviating the mitochondrial dysfunction would contribute to attenuating the severity or progression of the disease. Therefore, this review will examine the role of mitochondria in the etiology and progression of several diseases and explore potential therapeutic benefits of targeting mitochondria in mitigating the disease processes. Indeed, recent advances in mitochondrial biology have led to selective targeting of drugs designed to modulate and manipulate mitochondrial function and genomics for therapeutic benefit. These approaches to treat mitochondrial dysfunction rationally could lead to selective protection of cells in different tissues and various disease states. However, most of these approaches are in their infancy.</description><subject>Aging</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Apoptosis</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Comprehensive Invited Reviews</subject><subject>Disease</subject><subject>DNA, Mitochondrial - metabolism</subject><subject>Drug Design</subject><subject>Electron Transport - physiology</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Life Expectancy</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - physiology</subject><subject>Mitochondria - ultrastructure</subject><subject>Mitochondrial diseases</subject><subject>Mitochondrial Proteins - metabolism</subject><subject>Oxidative Phosphorylation</subject><subject>Physiological aspects</subject><subject>Reactive Nitrogen Species - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>1523-0864</issn><issn>1557-7716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcFLHTEQxkNpqdb26FUWevC0z8lms0kugoi1BcEe9Byyyex7kd3NM8kT_O_N8qwolBwSJr_vY2Y-Qo4prChIdWZiWjUAatUIKT-RQ8q5qIWg3efl3bAaZNcekG8pPQBAQyl8JQdFAFS07SG5-hsyztmbscobjGaLu-xt1eOMg8-pCkOVcjQZ1x5T5XxEm9FVOVSTz8FuwuyiN9_Jl8GMCX-83kfk_tfV3eXv-ub2-s_lxU1tOVW5dqLrgVNHe2coyhYcc4phz5RtjVIU2kEOEhvHRM85qMEZZqVE5WSHUjl2RM73vttdP6GzpfNoRr2NfjLxWQfj9cef2W_0OjzpRrFOcV4MTl8NYnjcYcp68sniOJoZwy5pwRiDrhVdIX_uybUZUft5CMXQLrS-aBjj0MhuoVb_ocpxOHkbliWW-gdBvRfYGFKKOLw1T0EvgeoSqF4C1UughT95P_Eb_S9B9gK_j5zG</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Camara, Amadou K S</creator><creator>Lesnefsky, Edward J</creator><creator>Stowe, David F</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100801</creationdate><title>Potential therapeutic benefits of strategies directed to mitochondria</title><author>Camara, Amadou K S ; Lesnefsky, Edward J ; Stowe, David F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-d76b051d1bda1e840d3d93eb39c4a99104f8f8e2d37b5509fda3c88e9d86e89d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Apoptosis</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Comprehensive Invited Reviews</topic><topic>Disease</topic><topic>DNA, Mitochondrial - metabolism</topic><topic>Drug Design</topic><topic>Electron Transport - physiology</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Life Expectancy</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - physiology</topic><topic>Mitochondria - ultrastructure</topic><topic>Mitochondrial diseases</topic><topic>Mitochondrial Proteins - metabolism</topic><topic>Oxidative Phosphorylation</topic><topic>Physiological aspects</topic><topic>Reactive Nitrogen Species - metabolism</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camara, Amadou K S</creatorcontrib><creatorcontrib>Lesnefsky, Edward J</creatorcontrib><creatorcontrib>Stowe, David F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antioxidants & redox signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camara, Amadou K S</au><au>Lesnefsky, Edward J</au><au>Stowe, David F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential therapeutic benefits of strategies directed to mitochondria</atitle><jtitle>Antioxidants & redox signaling</jtitle><addtitle>Antioxid Redox Signal</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>13</volume><issue>3</issue><spage>279</spage><epage>347</epage><pages>279-347</pages><issn>1523-0864</issn><eissn>1557-7716</eissn><abstract>The mitochondrion is the most important organelle in determining continued cell survival and cell death. Mitochondrial dysfunction leads to many human maladies, including cardiovascular diseases, neurodegenerative disease, and cancer. These mitochondria-related pathologies range from early infancy to senescence. The central premise of this review is that if mitochondrial abnormalities contribute to the pathological state, alleviating the mitochondrial dysfunction would contribute to attenuating the severity or progression of the disease. Therefore, this review will examine the role of mitochondria in the etiology and progression of several diseases and explore potential therapeutic benefits of targeting mitochondria in mitigating the disease processes. Indeed, recent advances in mitochondrial biology have led to selective targeting of drugs designed to modulate and manipulate mitochondrial function and genomics for therapeutic benefit. These approaches to treat mitochondrial dysfunction rationally could lead to selective protection of cells in different tissues and various disease states. However, most of these approaches are in their infancy.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>20001744</pmid><doi>10.1089/ars.2009.2788</doi><tpages>69</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1523-0864 |
ispartof | Antioxidants & redox signaling, 2010-08, Vol.13 (3), p.279-347 |
issn | 1523-0864 1557-7716 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2936955 |
source | MEDLINE; Alma/SFX Local Collection |
subjects | Aging Animals Antioxidants - metabolism Apoptosis Care and treatment Complications and side effects Comprehensive Invited Reviews Disease DNA, Mitochondrial - metabolism Drug Design Electron Transport - physiology Genetic aspects Humans Life Expectancy Mitochondria - drug effects Mitochondria - physiology Mitochondria - ultrastructure Mitochondrial diseases Mitochondrial Proteins - metabolism Oxidative Phosphorylation Physiological aspects Reactive Nitrogen Species - metabolism Reactive Oxygen Species - metabolism |
title | Potential therapeutic benefits of strategies directed to mitochondria |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T06%3A16%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potential%20therapeutic%20benefits%20of%20strategies%20directed%20to%20mitochondria&rft.jtitle=Antioxidants%20&%20redox%20signaling&rft.au=Camara,%20Amadou%20K%20S&rft.date=2010-08-01&rft.volume=13&rft.issue=3&rft.spage=279&rft.epage=347&rft.pages=279-347&rft.issn=1523-0864&rft.eissn=1557-7716&rft_id=info:doi/10.1089/ars.2009.2788&rft_dat=%3Cgale_pubme%3EA233502866%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733306476&rft_id=info:pmid/20001744&rft_galeid=A233502866&rfr_iscdi=true |