The role of nitric oxide, superoxide and peroxynitrite in the anti‐arrhythmic effects of preconditioning and peroxynitrite infusion in anaesthetized dogs

Background and purpose: Both ischaemia preconditioning (PC) and the intracoronary infusion of peroxynitrite (PN) suppress ischaemia and reperfusion (I/R)‐induced arrhythmias and the generation of nitrotyrosine (NT, a marker of PN). However, it is still unclear whether this latter effect is due to a...

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Veröffentlicht in:	British journal of pharmacology 2010-07, Vol.160 (5), p.1263-1272
Hauptverfasser:	Kiss, Attila, Juhász, László, Seprényi, György, Kupai, Krisztina, Kaszaki, József, Végh, Ágnes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - administration & dosage Anti-Arrhythmia Agents - pharmacology arrhythmias Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - physiopathology Biological and medical sciences Cardiac arrhythmia Cardiac dysrhythmias Cardiology. Vascular system Dogs Female Heart Infusions, Intra-Arterial Ischemic Preconditioning, Myocardial - methods Male Medical sciences Nitric oxide Nitric Oxide - metabolism peroxynitrite Peroxynitrous Acid - administration & dosage Peroxynitrous Acid - pharmacology Pharmacology. Drug treatments preconditioning Reactive Nitrogen Species - metabolism Research Papers superoxide Superoxides - metabolism Tyrosine - analogs & derivatives Tyrosine - metabolism
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