Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders

The reduced expression of the Sp4 gene in Sp4 hypomorphic mice resulted in subtle vacuolization in the hippocampus as well as deficits in sensorimotor gating and contextual memory, putative endophenotypes for schizophrenia and other psychiatric disorders. In this study, we examined both spatial lear...

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Veröffentlicht in:	Human molecular genetics 2010-10, Vol.19 (19), p.3797-3805
Hauptverfasser:	Zhou, Xianjin, Nie, Zhiguo, Roberts, Amanda, Zhang, Dongxian, Sebat, Jonathan, Malhotra, Dheeraj, Kelsoe, John R., Geyer, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CA1 Region, Hippocampal - pathology CA1 Region, Hippocampal - physiopathology Electrophysiological Phenomena Endophenotypes - metabolism Fundamental and applied biological sciences. Psychology Gene Deletion Genetics of eukaryotes. Biological and molecular evolution Homozygote Humans Long-Term Potentiation - physiology Maze Learning Mental Disorders - metabolism Mental Disorders - physiopathology Mice Molecular and cellular biology Protein Subunits - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Schizophrenia - genetics Schizophrenia - physiopathology Sp4 Transcription Factor - genetics Sp4 Transcription Factor - metabolism
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