Association of the GABRD gene and childhood‐onset mood disorders
The chromosome 1p36 region was previously indicated as a locus for susceptibility to recurrent major depressive disorder based on a linkage study in a sample of 497 sib pairs. We investigated the gamma‐aminobutyric acid A (GABAA) δ receptor subunit gene, GABRD, as a susceptibility gene to childhood‐...
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| creator | Feng, Y. Kapornai, K. Kiss, E. Tamás, Z. Mayer, L. Baji, I. Daróczi, G. Benák, I. Kothencné, V. O. Dombovári, E. Kaczvinszk, E. Besnyő, M. Gádoros, J. Székely, J. Kovacs, M. Vetró, Á. Kennedy, J. L. Barr, C. L. |
| description | The chromosome 1p36 region was previously indicated as a locus for susceptibility to recurrent major depressive disorder based on a linkage study in a sample of 497 sib pairs. We investigated the gamma‐aminobutyric acid A (GABAA) δ receptor subunit gene, GABRD, as a susceptibility gene to childhood‐onset mood disorders (COMD) because of substantial evidence implicating GABAergic dysfunction in mood disorders and the position of this gene near the 1p36 linkage region. Using a sample consisting of 645 Hungarian families with a child/adolescent proband diagnosed with a mood disorder with the onset of the first episode before age 15, we found some evidence for the association of two polymorphisms located within the gene, rs2376805 and rs2376803, as well as significant evidence for biased transmission of the haplotypes of these two markers (global χ2 test for haplotypes = 12.746, 3 df, P = 0.0052). Furthermore, significant evidence of association was only observed in male subjects (n = 438) when the results were analyzed by sex (χ2 = 9.000 1 df, P = 0.003 for rs2376805). This was in contrast with the previous linkage findings, as LOD scores exceeding 3 were only in female–female pairs in that study. These findings point to the GABRD gene as a susceptibility gene for COMD; however, this gene may not explain the previous linkage finding. |
| doi_str_mv | 10.1111/j.1601-183X.2010.00598.x |
| format | Article |
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O. ; Dombovári, E. ; Kaczvinszk, E. ; Besnyő, M. ; Gádoros, J. ; Székely, J. ; Kovacs, M. ; Vetró, Á. ; Kennedy, J. L. ; Barr, C. L.</creator><creatorcontrib>Feng, Y. ; Kapornai, K. ; Kiss, E. ; Tamás, Z. ; Mayer, L. ; Baji, I. ; Daróczi, G. ; Benák, I. ; Kothencné, V. O. ; Dombovári, E. ; Kaczvinszk, E. ; Besnyő, M. ; Gádoros, J. ; Székely, J. ; Kovacs, M. ; Vetró, Á. ; Kennedy, J. L. ; Barr, C. L.</creatorcontrib><description>The chromosome 1p36 region was previously indicated as a locus for susceptibility to recurrent major depressive disorder based on a linkage study in a sample of 497 sib pairs. We investigated the gamma‐aminobutyric acid A (GABAA) δ receptor subunit gene, GABRD, as a susceptibility gene to childhood‐onset mood disorders (COMD) because of substantial evidence implicating GABAergic dysfunction in mood disorders and the position of this gene near the 1p36 linkage region. Using a sample consisting of 645 Hungarian families with a child/adolescent proband diagnosed with a mood disorder with the onset of the first episode before age 15, we found some evidence for the association of two polymorphisms located within the gene, rs2376805 and rs2376803, as well as significant evidence for biased transmission of the haplotypes of these two markers (global χ2 test for haplotypes = 12.746, 3 df, P = 0.0052). Furthermore, significant evidence of association was only observed in male subjects (n = 438) when the results were analyzed by sex (χ2 = 9.000 1 df, P = 0.003 for rs2376805). This was in contrast with the previous linkage findings, as LOD scores exceeding 3 were only in female–female pairs in that study. These findings point to the GABRD gene as a susceptibility gene for COMD; however, this gene may not explain the previous linkage finding.</description><identifier>ISSN: 1601-1848</identifier><identifier>EISSN: 1601-183X</identifier><identifier>DOI: 10.1111/j.1601-183X.2010.00598.x</identifier><identifier>PMID: 20561060</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescence ; Adolescent ; Age ; Age of Onset ; Child ; Chromosome 1 ; chromosome 1p ; Depression ; Female ; g-Aminobutyric acid ; g-Aminobutyric acid A receptors ; GABA ; GABA receptors ; GABRD ; gamma-Aminobutyric Acid - metabolism ; Gene polymorphism ; genetics ; Genotype ; Haplotypes ; Haplotypes - genetics ; Humans ; Hungary - epidemiology ; Linkage Disequilibrium - genetics ; Male ; Mood ; mood disorders ; Mood Disorders - epidemiology ; Mood Disorders - genetics ; Neurotransmission ; Nuclear Family ; Polymorphism, Single Nucleotide ; Receptors, GABA-A - genetics ; Sex ; Sex Factors</subject><ispartof>Genes, brain and behavior, 2010-08, Vol.9 (6), p.668-672</ispartof><rights>2010 The Authors. 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O.</creatorcontrib><creatorcontrib>Dombovári, E.</creatorcontrib><creatorcontrib>Kaczvinszk, E.</creatorcontrib><creatorcontrib>Besnyő, M.</creatorcontrib><creatorcontrib>Gádoros, J.</creatorcontrib><creatorcontrib>Székely, J.</creatorcontrib><creatorcontrib>Kovacs, M.</creatorcontrib><creatorcontrib>Vetró, Á.</creatorcontrib><creatorcontrib>Kennedy, J. L.</creatorcontrib><creatorcontrib>Barr, C. L.</creatorcontrib><title>Association of the GABRD gene and childhood‐onset mood disorders</title><title>Genes, brain and behavior</title><addtitle>Genes Brain Behav</addtitle><description>The chromosome 1p36 region was previously indicated as a locus for susceptibility to recurrent major depressive disorder based on a linkage study in a sample of 497 sib pairs. We investigated the gamma‐aminobutyric acid A (GABAA) δ receptor subunit gene, GABRD, as a susceptibility gene to childhood‐onset mood disorders (COMD) because of substantial evidence implicating GABAergic dysfunction in mood disorders and the position of this gene near the 1p36 linkage region. Using a sample consisting of 645 Hungarian families with a child/adolescent proband diagnosed with a mood disorder with the onset of the first episode before age 15, we found some evidence for the association of two polymorphisms located within the gene, rs2376805 and rs2376803, as well as significant evidence for biased transmission of the haplotypes of these two markers (global χ2 test for haplotypes = 12.746, 3 df, P = 0.0052). Furthermore, significant evidence of association was only observed in male subjects (n = 438) when the results were analyzed by sex (χ2 = 9.000 1 df, P = 0.003 for rs2376805). This was in contrast with the previous linkage findings, as LOD scores exceeding 3 were only in female–female pairs in that study. These findings point to the GABRD gene as a susceptibility gene for COMD; however, this gene may not explain the previous linkage finding.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Child</subject><subject>Chromosome 1</subject><subject>chromosome 1p</subject><subject>Depression</subject><subject>Female</subject><subject>g-Aminobutyric acid</subject><subject>g-Aminobutyric acid A receptors</subject><subject>GABA</subject><subject>GABA receptors</subject><subject>GABRD</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Gene polymorphism</subject><subject>genetics</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Hungary - epidemiology</subject><subject>Linkage Disequilibrium - genetics</subject><subject>Male</subject><subject>Mood</subject><subject>mood disorders</subject><subject>Mood Disorders - epidemiology</subject><subject>Mood Disorders - genetics</subject><subject>Neurotransmission</subject><subject>Nuclear Family</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, GABA-A - genetics</subject><subject>Sex</subject><subject>Sex Factors</subject><issn>1601-1848</issn><issn>1601-183X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd1KwzAUx4Mofr-C5M6rzaRp0gRE2KZOYSCIgnchTU-3jK6ZTefHnY_gM_oktm4OvdLc5CTnd_4k_BDClHRps06mXSoI7VDJHroRaW4J4Up2XzbQ7rqxua5juYP2QpgSQhMm6TbaiQgXlAiyi_q9ELx1pna-xD7H9QTwsNe_PcdjKAGbMsN24ops4n328fbuywA1njUHnLngqwyqcIC2clMEOFzt--j-8uJucNUZ3QyvB71Rx3ISy45KubQsVhZSKqSNhEpEmjBLQNHUSGI5YzYGA4lSOTEGVBLlmZIm5zmzOWH76GyZO1-kM8gslHVlCj2v3MxUr9obp393SjfRY_-kI8W4kEkTcLwKqPzjAkKtZy5YKApTgl8EnfCYM0G5-puMpYqjhIuGlEvSVj6ECvL1eyjRrSs91a0G3SrRrSv95Uq_NKNHP_-zHvyW0wCnS-DZFfD672A97Pebgn0C-w2kJA</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Feng, Y.</creator><creator>Kapornai, K.</creator><creator>Kiss, E.</creator><creator>Tamás, Z.</creator><creator>Mayer, L.</creator><creator>Baji, I.</creator><creator>Daróczi, G.</creator><creator>Benák, I.</creator><creator>Kothencné, V. O.</creator><creator>Dombovári, E.</creator><creator>Kaczvinszk, E.</creator><creator>Besnyő, M.</creator><creator>Gádoros, J.</creator><creator>Székely, J.</creator><creator>Kovacs, M.</creator><creator>Vetró, Á.</creator><creator>Kennedy, J. L.</creator><creator>Barr, C. L.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>201008</creationdate><title>Association of the GABRD gene and childhood‐onset mood disorders</title><author>Feng, Y. ; Kapornai, K. ; Kiss, E. ; Tamás, Z. ; Mayer, L. ; Baji, I. ; Daróczi, G. ; Benák, I. ; Kothencné, V. O. ; Dombovári, E. ; Kaczvinszk, E. ; Besnyő, M. ; Gádoros, J. ; Székely, J. ; Kovacs, M. ; Vetró, Á. ; Kennedy, J. 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L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes, brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Feng, Y.</au><au>Kapornai, K.</au><au>Kiss, E.</au><au>Tamás, Z.</au><au>Mayer, L.</au><au>Baji, I.</au><au>Daróczi, G.</au><au>Benák, I.</au><au>Kothencné, V. O.</au><au>Dombovári, E.</au><au>Kaczvinszk, E.</au><au>Besnyő, M.</au><au>Gádoros, J.</au><au>Székely, J.</au><au>Kovacs, M.</au><au>Vetró, Á.</au><au>Kennedy, J. L.</au><au>Barr, C. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the GABRD gene and childhood‐onset mood disorders</atitle><jtitle>Genes, brain and behavior</jtitle><addtitle>Genes Brain Behav</addtitle><date>2010-08</date><risdate>2010</risdate><volume>9</volume><issue>6</issue><spage>668</spage><epage>672</epage><pages>668-672</pages><issn>1601-1848</issn><eissn>1601-183X</eissn><abstract>The chromosome 1p36 region was previously indicated as a locus for susceptibility to recurrent major depressive disorder based on a linkage study in a sample of 497 sib pairs. We investigated the gamma‐aminobutyric acid A (GABAA) δ receptor subunit gene, GABRD, as a susceptibility gene to childhood‐onset mood disorders (COMD) because of substantial evidence implicating GABAergic dysfunction in mood disorders and the position of this gene near the 1p36 linkage region. Using a sample consisting of 645 Hungarian families with a child/adolescent proband diagnosed with a mood disorder with the onset of the first episode before age 15, we found some evidence for the association of two polymorphisms located within the gene, rs2376805 and rs2376803, as well as significant evidence for biased transmission of the haplotypes of these two markers (global χ2 test for haplotypes = 12.746, 3 df, P = 0.0052). Furthermore, significant evidence of association was only observed in male subjects (n = 438) when the results were analyzed by sex (χ2 = 9.000 1 df, P = 0.003 for rs2376805). This was in contrast with the previous linkage findings, as LOD scores exceeding 3 were only in female–female pairs in that study. These findings point to the GABRD gene as a susceptibility gene for COMD; however, this gene may not explain the previous linkage finding.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20561060</pmid><doi>10.1111/j.1601-183X.2010.00598.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescence Adolescent Age Age of Onset Child Chromosome 1 chromosome 1p Depression Female g-Aminobutyric acid g-Aminobutyric acid A receptors GABA GABA receptors GABRD gamma-Aminobutyric Acid - metabolism Gene polymorphism genetics Genotype Haplotypes Haplotypes - genetics Humans Hungary - epidemiology Linkage Disequilibrium - genetics Male Mood mood disorders Mood Disorders - epidemiology Mood Disorders - genetics Neurotransmission Nuclear Family Polymorphism, Single Nucleotide Receptors, GABA-A - genetics Sex Sex Factors |
| title | Association of the GABRD gene and childhood‐onset mood disorders |
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