Inactivation of Patched1 in the Mouse Limb Has Novel Inhibitory Effects on the Chondrogenic Program

The bones of the vertebrate limb form by the process of endochondral ossification, whereby limb mesenchyme condenses to form an intermediate cartilage scaffold that is then replaced by bone. Although Indian hedgehog (IHH) is known to control hypertophic differentiation of chondrocytes during this pr...

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Veröffentlicht in:	The Journal of biological chemistry 2010-09, Vol.285 (36), p.27967-27981
Hauptverfasser:	Bruce, Stephen J., Butterfield, Natalie C., Metzis, Vicki, Town, Liam, McGlinn, Edwina, Wicking, Carol
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Death Cell Differentiation Cells, Cultured Chondrocytes - cytology Chondrocytes - metabolism Chondrogenesis Development Developmental Biology Embryo Extremities - physiology Female Forelimb - metabolism Forelimb - physiology Hedgehog Proteins - metabolism Hindlimb - metabolism Hindlimb - physiology Homeodomain Proteins - genetics Ligands Limb Development Male Mice Mice, Transgenic Molecular Imaging Mouse Genetics Patched Receptors Patched-1 Receptor Patched1 Peanut Agglutinin - metabolism Phenotype prx1-cre Receptors, Cell Surface - deficiency Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Sonic Hedgehog Pathway Staining and Labeling Time Factors
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