The effect of chronic administration of l-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
The present study was carried out to evaluate the effect of l-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats. Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-...
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| Veröffentlicht in: | Clinics (São Paulo, Brazil) Brazil), 2010-08, Vol.65 (8), p.803-807 |
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| container_title | Clinics (São Paulo, Brazil) |
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| creator | Hosseini, Mahmoud Headari, Raheleh Oryan, Sharbanoo Hadjzadeh, Mosa Alreza Saffarzadeh, Fatima Khazaei, Majid |
| description | The present study was carried out to evaluate the effect of l-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats.
Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of l-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups.
Time latency and path length in the OVX group were significantly higher than in the sham group (P |
| doi_str_mv | 10.1590/S1807-59322020000800012 |
| format | Article |
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Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of l-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups.
Time latency and path length in the OVX group were significantly higher than in the sham group (P<0.05). The OVX-Est group had a significantly shorter traveled path length and time latency compared to the OVX group (P<0.001). Time latency and path length in the sham-Est group was significantly higher than in the sham group (P<0.001). Time latency and path length in the OVX-Est-LA group were significantly higher than in the OVX-Est group.
These results allow us to propose that chronic treatment with estradiol enhances the spatial learning and memory of OVX rats, and that long term l-arginine treatment attenuates the effects of improvement produced by estradiol in OVX rats.</description><identifier>ISSN: 1807-5932</identifier><identifier>EISSN: 1980-5322</identifier><identifier>DOI: 10.1590/S1807-59322020000800012</identifier><identifier>PMID: 20835559</identifier><language>eng</language><publisher>Elsevier España, S.L.U</publisher><subject>Basic Research ; Estradiol ; L-arginine ; Morris water maze ; Ovariectomy</subject><ispartof>Clinics (São Paulo, Brazil), 2010-08, Vol.65 (8), p.803-807</ispartof><rights>2010 CLINICS</rights><rights>Copyright © 2010 Hospital das Clínicas da FMUSP 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933129/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933129/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Hosseini, Mahmoud</creatorcontrib><creatorcontrib>Headari, Raheleh</creatorcontrib><creatorcontrib>Oryan, Sharbanoo</creatorcontrib><creatorcontrib>Hadjzadeh, Mosa Alreza</creatorcontrib><creatorcontrib>Saffarzadeh, Fatima</creatorcontrib><creatorcontrib>Khazaei, Majid</creatorcontrib><title>The effect of chronic administration of l-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze</title><title>Clinics (São Paulo, Brazil)</title><description>The present study was carried out to evaluate the effect of l-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats.
Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of l-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups.
Time latency and path length in the OVX group were significantly higher than in the sham group (P<0.05). The OVX-Est group had a significantly shorter traveled path length and time latency compared to the OVX group (P<0.001). Time latency and path length in the sham-Est group was significantly higher than in the sham group (P<0.001). Time latency and path length in the OVX-Est-LA group were significantly higher than in the OVX-Est group.
These results allow us to propose that chronic treatment with estradiol enhances the spatial learning and memory of OVX rats, and that long term l-arginine treatment attenuates the effects of improvement produced by estradiol in OVX rats.</description><subject>Basic Research</subject><subject>Estradiol</subject><subject>L-arginine</subject><subject>Morris water maze</subject><subject>Ovariectomy</subject><issn>1807-5932</issn><issn>1980-5322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNplUdtOAyEQJUbjpfoN8gOrXEoLLyam8ZY08cH6TCgMLWZ3adi1pv0Qv9ep1QcjCTBz5pzDkCHkkrMrrgy7fuGajStlpBBMMFwaNxcH5JQbzSqF-CHGv6QTctZ1b4xJI4fqmJwIpqVSypySz9kSKMQIvqc5Ur8suU2eutCkNnV9cX3K7a5SV64sEGuBItCjqgZXMF9Q1wbaQJPLZkeEnSqkXFd9AddDoHntSsIHcpO2mKJnR3ukYZz2VqgtqaMfSC-0cVs4J0fR1R1c_NwD8np_N5s8VtPnh6fJ7bQCMdJ9xaMCY2QAPY5i6IJ30SDGpA9KzLURKnphJOMSIGql9VjIoRd-JKTybqTlgNzsfVfv8waChxabr-2qpMaVjc0u2b-VNi3tIq8tukqOx4Dc7g0Au1wnKLbzCVoPIRX8sg05Wc7sbmj2e2j239DkF9x0jhA</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Hosseini, Mahmoud</creator><creator>Headari, Raheleh</creator><creator>Oryan, Sharbanoo</creator><creator>Hadjzadeh, Mosa Alreza</creator><creator>Saffarzadeh, Fatima</creator><creator>Khazaei, Majid</creator><general>Elsevier España, S.L.U</general><general>Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo</general><scope>6I.</scope><scope>AAFTH</scope><scope>5PM</scope></search><sort><creationdate>20100801</creationdate><title>The effect of chronic administration of l-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze</title><author>Hosseini, Mahmoud ; Headari, Raheleh ; Oryan, Sharbanoo ; Hadjzadeh, Mosa Alreza ; Saffarzadeh, Fatima ; Khazaei, Majid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e268t-1f5e993de87f24adcaf91f503cd52b8925fc293013eef85887234c2c6235ca683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Basic Research</topic><topic>Estradiol</topic><topic>L-arginine</topic><topic>Morris water maze</topic><topic>Ovariectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosseini, Mahmoud</creatorcontrib><creatorcontrib>Headari, Raheleh</creatorcontrib><creatorcontrib>Oryan, Sharbanoo</creatorcontrib><creatorcontrib>Hadjzadeh, Mosa Alreza</creatorcontrib><creatorcontrib>Saffarzadeh, Fatima</creatorcontrib><creatorcontrib>Khazaei, Majid</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinics (São Paulo, Brazil)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hosseini, Mahmoud</au><au>Headari, Raheleh</au><au>Oryan, Sharbanoo</au><au>Hadjzadeh, Mosa Alreza</au><au>Saffarzadeh, Fatima</au><au>Khazaei, Majid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of chronic administration of l-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze</atitle><jtitle>Clinics (São Paulo, Brazil)</jtitle><date>2010-08-01</date><risdate>2010</risdate><volume>65</volume><issue>8</issue><spage>803</spage><epage>807</epage><pages>803-807</pages><issn>1807-5932</issn><eissn>1980-5322</eissn><abstract>The present study was carried out to evaluate the effect of l-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats.
Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of l-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups.
Time latency and path length in the OVX group were significantly higher than in the sham group (P<0.05). The OVX-Est group had a significantly shorter traveled path length and time latency compared to the OVX group (P<0.001). Time latency and path length in the sham-Est group was significantly higher than in the sham group (P<0.001). Time latency and path length in the OVX-Est-LA group were significantly higher than in the OVX-Est group.
These results allow us to propose that chronic treatment with estradiol enhances the spatial learning and memory of OVX rats, and that long term l-arginine treatment attenuates the effects of improvement produced by estradiol in OVX rats.</abstract><pub>Elsevier España, S.L.U</pub><pmid>20835559</pmid><doi>10.1590/S1807-59322020000800012</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Basic Research Estradiol L-arginine Morris water maze Ovariectomy |
| title | The effect of chronic administration of l-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze |
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