Excitation-contraction coupling and minor triadic proteins in low-frequency fatigue

Low-frequency fatigue (LFF) is characterized by a proportionally greater loss of force at low compared with high activation frequencies and a prolonged recovery. Recent work suggests a calcium-induced uncoupling of excitation-contraction coupling underlies LFF. Here, newly characterized triadic prot...

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Veröffentlicht in:Exercise and sport sciences reviews 2010-07, Vol.38 (3), p.135-142
1. Verfasser: Balog, Edward M
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description Low-frequency fatigue (LFF) is characterized by a proportionally greater loss of force at low compared with high activation frequencies and a prolonged recovery. Recent work suggests a calcium-induced uncoupling of excitation-contraction coupling underlies LFF. Here, newly characterized triadic proteins are described, and possible mechanisms by which they may contribute to LFF are suggested.
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source MEDLINE; Journals@Ovid LWW Legacy Archive; EZB-FREE-00999 freely available EZB journals
subjects Animals
Calcium - physiology
Calcium Channels - physiology
Excitation Contraction Coupling - physiology
Humans
Membrane Proteins - physiology
Mice
Muscle Contraction - physiology
Muscle Fatigue - physiology
Muscle Proteins - physiology
Muscle, Skeletal - physiology
Ryanodine Receptor Calcium Release Channel - physiology
Sarcoplasmic Reticulum - physiology
title Excitation-contraction coupling and minor triadic proteins in low-frequency fatigue
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