Niacin treatment of stroke increases synaptic plasticity and axon growth in rats

Niacin is the most effective medication in current clinical use for increasing high-density lipoprotein cholesterol. We tested the hypothesis that niacin treatment of stroke promotes synaptic plasticity and axon growth in the ischemic brain. Male Wistar rats were subjected to 2 hours of middle cereb...

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Veröffentlicht in:	Stroke (1970) 2010-09, Vol.41 (9), p.2044-2049
Hauptverfasser:	Cui, Xu, Chopp, Michael, Zacharek, Alex, Roberts, Cynthia, Buller, Benjamin, Ion, Madalina, Chen, Jieli
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Axons - drug effects Blotting, Western Brain-Derived Neurotrophic Factor - metabolism Cells, Cultured GPI-Linked Proteins Immunohistochemistry Male Myelin Proteins Neuronal Plasticity - drug effects Neurons - drug effects Neurons - metabolism Niacin - pharmacology Niacin - therapeutic use Nogo Receptor 1 Rats Rats, Wistar Receptor, trkB - metabolism Receptors, Cell Surface Receptors, Peptide - metabolism Reverse Transcriptase Polymerase Chain Reaction Stroke - drug therapy Stroke - metabolism Synaptophysin - metabolism
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