Structural basis for the regulation of NtcA-dependent transcription by proteins PipX and PII

PII, an ancient and widespread signaling protein, transduces nitrogen/carbon/energy abundance signals through interactions with target proteins. We clarify structurally how PII regulates gene expression mediated by the transcription factor NtcA, the global nitrogen regulator of cyanobacteria, sheddi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-08, Vol.107 (35), p.15397-15402
Hauptverfasser:	Llácer, José L., Espinosa, Javier, Castells, Miguel A., Contreras, Asunción, Forchhammer, Karl, Rubio, Vicente, Haselkorn, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Binding Sites - genetics Biochemistry Biological Sciences Crystal structure Crystallization Crystallography, X-Ray Cyanobacteria Dimers DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Electrophoresis, Polyacrylamide Gel Gene expression Gene expression regulation Genetic mutation Gram-negative bacteria Ketoglutaric Acids - pharmacology Kinetics Models, Molecular Molecules Mutagenesis Mutagenesis, Site-Directed Mutation Nitrogen Phosphorylation PII Nitrogen Regulatory Proteins - chemistry PII Nitrogen Regulatory Proteins - genetics PII Nitrogen Regulatory Proteins - metabolism Protein Binding Protein Conformation Protein Multimerization Protein Structure, Tertiary Proteins Structure-Activity Relationship Surface Plasmon Resonance Synechococcus - genetics Synechococcus - metabolism Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - drug effects Two-Hybrid System Techniques
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