Circadian Gene Expression Regulates Pulsatile Gonadotropin-Releasing Hormone (GnRH) Secretory Patterns in the Hypothalamic GnRH-Secreting GT1-7 Cell Line

Although it has long been established that episodic secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus is required for normal gonadotropin release, the molecular and cellular mechanisms underlying the synchronous release of GnRH are primarily unknown. We used the GT1-7 mouse hy...

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Veröffentlicht in:	The Journal of neuroscience 2003-12, Vol.23 (35), p.11202-11213
Hauptverfasser:	Chappell, Patrick E, White, Rachel S, Mellon, Pamela L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARNTL Transcription Factors Basic Helix-Loop-Helix Transcription Factors Biological Clocks - genetics Biological Clocks - physiology Cell Cycle Proteins Cell Line Cellular/Molecular Circadian Rhythm - genetics Circadian Rhythm - physiology CLOCK Proteins Cryptochromes Drosophila Proteins Estrus - genetics Estrus - physiology Eye Proteins Fibroblasts - cytology Fibroblasts - metabolism Flavoproteins - genetics Gene Expression Regulation - physiology Gonadotropin-Releasing Hormone - biosynthesis Gonadotropin-Releasing Hormone - genetics Gonadotropin-Releasing Hormone - metabolism Green Fluorescent Proteins Hypothalamus - cytology Hypothalamus - metabolism Luminescent Proteins - genetics Mice Mice, Mutant Strains NIH 3T3 Cells Nuclear Proteins - genetics Nuclear Proteins - metabolism Period Circadian Proteins Photoreceptor Cells, Invertebrate Receptors, G-Protein-Coupled Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA, Messenger - metabolism Trans-Activators - genetics Transcription Factors - genetics Transcription Factors - metabolism
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