Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

Pro-cancer antioxidants There is laboratory evidence from in vitro and animal studies to suggest that antioxidants may suppress the development of cancer, though there is little conclusive evidence as to their effect in clinical conditions. Nevertheless it comes as something of a surprise to find th...

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Veröffentlicht in:	Nature (London) 2009-09, Vol.461 (7260), p.109-113
Hauptverfasser:	Schafer, Zachary T., Grassian, Alexandra R., Song, Loling, Jiang, Zhenyang, Gerhart-Hines, Zachary, Irie, Hanna Y., Gao, Sizhen, Puigserver, Pere, Brugge, Joan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Anoikis - physiology Antioxidants Antioxidants - metabolism Biological and medical sciences Breast - cytology Breast - metabolism Breast - pathology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Adhesion Cell Line Cell metabolism Cell physiology Cell Survival Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells Enzyme Activation Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial Cells - pathology Extracellular Matrix - metabolism Fatty Acids - metabolism Fundamental and applied biological sciences. Psychology Genetic aspects Glucose - metabolism Humanities and Social Sciences Humans Kinases letter Metabolic disorders Molecular and cellular biology multidisciplinary Oncogenes Oncogenes - genetics Oncogenes - physiology Pentose Phosphate Pathway - physiology Phosphatidylinositol 3-Kinases - metabolism Physiological aspects Reactive Oxygen Species - metabolism Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Science Studies
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